Literature summary for 4.1.1.28 extracted from

Menheniott, T.R.; Woodfine, K.; Schulz, R.; Wood, A.J.; Monk, D.; Giraud, A.S.; Baldwin, H.S.; Moore, G.E.; Oakey, R.J.
Genomic imprinting of Dopa decarboxylase in heart and reciprocal allelic expression with neighboring Grb10 (2008), Mol. Cell. Biol., 28, 386-396.

Search for more literature for 4.1.1.28

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-Dopa	Mus musculus	biosynthesis of catecholamine neurotransmitters and serotonin	dopamine + CO2	-	?
additional information	Mus musculus	the imprinting and developmental regulation of Ddc_exon1a expression in the heart suggests fundamental roles in cardiogenesis and cardiac function	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	O88533	parental allele identity is inferred via a G3A single-nucleotide polymorphism between the Mus musculus C57BL6 (B6) and Mus musculus castaneus CAST/Ei (CAST) strains in exon 6 at nucleotide 645	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Mus musculus	-
heart	novel imprinted dopa decarbylase gene on chromosome 11 is a 2kb transcript variant that initiates from an alternative first exon in intron 1 of the canonical Ddc transcript, it is paternally expressed in trabecular cardiomyocytes of the embryonic and neonatal heart. Imprinted gene expression is progressively downregulated in the heart during postnatal development and occurs only at low basal levels in the adult heart.	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-Dopa	biosynthesis of catecholamine neurotransmitters and serotonin	Mus musculus	dopamine + CO2	-	?
additional information	the imprinting and developmental regulation of Ddc_exon1a expression in the heart suggests fundamental roles in cardiogenesis and cardiac function	Mus musculus	?	-	?

Synonyms

Synonyms	Comment	Organism
DDC	-	Mus musculus
DOPA decarboxylase	-	Mus musculus

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Release 2023.1 (January 2023)