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Literature summary for 4.1.1.28 extracted from

  • Lopez-Contreras, A.J.; Galindo, J.D.; Lopez-Garcia, C.; Castells, M.T.; Cremades, A.; Penafiel, R.
    Opposite sexual dimorphism of 3,4-dihydroxyphenylalanine decarboxylase in the kidney and small intestine of mice (2008), J. Endocrinol., 196, 615-624.
    View publication on PubMed
Search for more literature for 4.1.1.28

Inhibitors

Inhibitors Comment Organism Structure
additional information in castrated male mice, DCC activity decreases in all parts of the small intestine, reaching values similar to those in females Mus musculus
testosterone propionate repetitive treatment of female mice with testosterone propionate for 2 weeks elicits a marked decrease in renal DCC activity Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Na+ inverse correlation between DDC activity and sodium reabsorption in the kidney, confirming the hypothesis that dopamine inhibits sodium absorption Mus musculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
54000
-
 predicted from amino acid sequence and determined by Western Blot analysis Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5-hydroxytryptophan Mus musculus
-
 5-hydroxytryptamine + CO2
-
 ?
L-Dopa Mus musculus
-
 dopamine + CO2
-
 ?
additional information Mus musculus DDC is involved in the synthesis of dopamine, serotonin and acts as an androgen receptor co-regulator protein ?
-
 ?
additional information Mus musculus the key step in the formation of the aromatic amines dopamine, epinephrine and norepinephrine is catalyzed by a single enzyme ?
-
 ?
phenylalanine Mus musculus
-
 phenylethylamine + CO2
-
 ?
Tryptophan Mus musculus
-
 Tryptamine + CO2
-
 ?
tyrosine Mus musculus
-
 tyramine + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 immature and adult Swiss CD1 mice
-

Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland
-
 Mus musculus
-
brain
-
 Mus musculus
-
colon
-
 Mus musculus
-
duodenum sexual dimorphism Mus musculus
-
heart
-
 Mus musculus
-
ileum sexual dimorphism Mus musculus
-
jejunum sexual dimorphism Mus musculus
-
kidney sexual dimorphism Mus musculus
-
liver
-
 Mus musculus
-
ovary
-
 Mus musculus
-
pancreas
-
 Mus musculus
-
prostate
-
 Mus musculus
-
skeletal muscle
-
 Mus musculus
-
testis
-
 Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 2076 nmol CO2/h/g wet female adrenal gland tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine Mus musculus
additional information
-
 21 nmol CO2/h/g wet female skeletal muscle tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine Mus musculus
additional information
-
 21 nmol CO2/h/g wet male testis tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine Mus musculus
additional information
-
 2174 nmol CO2/h/g wet male small intestine tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine Mus musculus
additional information
-
 2322 nmol CO2/h/g wet male adrenal gland tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine Mus musculus
additional information
-
 27 nmol CO2/h/g wet male skeletal muscle tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine Mus musculus
additional information
-
 310 nmol CO2/h/g wet male heart tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine Mus musculus
additional information
-
 3200 nmol CO2/h/g wet male liver tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine Mus musculus
additional information
-
 3247 nmol CO2/h/g wet female kidney tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine Mus musculus
additional information
-
 34 nmol CO2/h/g wet female ovary tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine Mus musculus
additional information
-
 3410 nmol CO2/h/g wet female liver tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine Mus musculus
additional information
-
 384 nmol CO2/h/g wet female small intestine tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine Mus musculus
additional information
-
 42 nmol CO2/h/g wet male prostate tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine Mus musculus
additional information
-
 457 nmol CO2/h/g wet male pancreas tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine Mus musculus
additional information
-
 476 nmol CO2/h/g wet female heart tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine Mus musculus
additional information
-
 533 nmol CO2/h/g wet female pancreas tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine Mus musculus
additional information
-
 636 nmol CO2/h/g wet male kidney tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine Mus musculus
additional information
-
 798 nmol CO2/h/g wet male brain, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine Mus musculus
additional information
-
 853 nmol CO2/h/g wet female brain tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine Mus musculus
additional information
-
 estrogen ablation or treatment with estradiol does not affect DDC activity Mus musculus
additional information
-
 in kidney, DNA and protein levels of DDC are remarkably higher in females than in males (sexual dimorphism) Mus musculus
additional information
-
 in the small intestine, male mice display higher levels of activity than females (sexual dimorphism) Mus musculus
additional information
-
 sexual dimorphism of DCC in kidney has physiological relevance in sodium homeostasis Mus musculus
additional information
-
 treatment of female mice with testosterone propionate elicits a robust increase in DCC activity in duodenum and jejunum, which is weaker in the ileum Mus musculus
additional information
-
 treatment of females with testosterone propionate for short periods of time (24 and 48 h) does not significantly affect renal DCC activity, although levels of mRNA produces a marked decrease in the kidney Mus musculus
additional information
-
 treatment of males with the antiandrogen flutamide for short periods of time (24 and 48 h) does not significantly affect renal DCC activity, although levels of mRNA produces a marked increase in the kidney Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-hydroxytryptophan
-
 Mus musculus 5-hydroxytryptamine + CO2
-
 ?
L-Dopa
-
 Mus musculus dopamine + CO2
-
 ?
additional information DDC is involved in the synthesis of dopamine, serotonin and acts as an androgen receptor co-regulator protein Mus musculus ?
-
 ?
additional information the key step in the formation of the aromatic amines dopamine, epinephrine and norepinephrine is catalyzed by a single enzyme Mus musculus ?
-
 ?
phenylalanine
-
 Mus musculus phenylethylamine + CO2
-
 ?
Tryptophan
-
 Mus musculus Tryptamine + CO2
-
 ?
tyrosine
-
 Mus musculus tyramine + CO2
-
 ?

Synonyms

Synonyms Comment Organism
3,4-Dihydroxyphenylalanine decarboxylase
-
 Mus musculus
AADC
-
 Mus musculus
Aromatic L-amino acid decarboxylase
-
 Mus musculus
DDC
-
 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
 assay at Mus musculus

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Mus musculus