BRENDA - Enzyme Database show
show all sequences of 4.1.1.28

Opposite sexual dimorphism of 3,4-dihydroxyphenylalanine decarboxylase in the kidney and small intestine of mice

Lopez-Contreras, A.J.; Galindo, J.D.; Lopez-Garcia, C.; Castells, M.T.; Cremades, A.; Penafiel, R.; J. Endocrinol. 196, 615-624 (2008)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
additional information
in castrated male mice, DCC activity decreases in all parts of the small intestine, reaching values similar to those in females
Mus musculus
testosterone propionate
repetitive treatment of female mice with testosterone propionate for 2 weeks elicits a marked decrease in renal DCC activity
Mus musculus
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Na+
inverse correlation between DDC activity and sodium reabsorption in the kidney, confirming the hypothesis that dopamine inhibits sodium absorption
Mus musculus
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
54000
-
predicted from amino acid sequence and determined by Western Blot analysis
Mus musculus
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5-hydroxytryptophan
Mus musculus
-
5-hydroxytryptamine + CO2
-
-
?
L-Dopa
Mus musculus
-
dopamine + CO2
-
-
?
additional information
Mus musculus
DDC is involved in the synthesis of dopamine, serotonin and acts as an androgen receptor co-regulator protein
?
-
-
-
additional information
Mus musculus
the key step in the formation of the aromatic amines dopamine, epinephrine and norepinephrine is catalyzed by a single enzyme
?
-
-
-
phenylalanine
Mus musculus
-
phenylethylamine + CO2
-
-
?
Tryptophan
Mus musculus
-
Tryptamine + CO2
-
-
?
tyrosine
Mus musculus
-
tyramine + CO2
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Mus musculus
-
immature and adult Swiss CD1 mice
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
adrenal gland
-
Mus musculus
-
brain
-
Mus musculus
-
colon
-
Mus musculus
-
duodenum
sexual dimorphism
Mus musculus
-
heart
-
Mus musculus
-
ileum
sexual dimorphism
Mus musculus
-
jejunum
sexual dimorphism
Mus musculus
-
kidney
sexual dimorphism
Mus musculus
-
liver
-
Mus musculus
-
ovary
-
Mus musculus
-
pancreas
-
Mus musculus
-
prostate
-
Mus musculus
-
skeletal muscle
-
Mus musculus
-
testis
-
Mus musculus
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
additional information
-
2076 nmol CO2/h/g wet female adrenal gland tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine; 2174 nmol CO2/h/g wet male small intestine tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine; 21 nmol CO2/h/g wet female skeletal muscle tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine; 21 nmol CO2/h/g wet male testis tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine; 2322 nmol CO2/h/g wet male adrenal gland tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine; 27 nmol CO2/h/g wet male skeletal muscle tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine; 310 nmol CO2/h/g wet male heart tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine; 3200 nmol CO2/h/g wet male liver tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine; 3247 nmol CO2/h/g wet female kidney tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine; 3410 nmol CO2/h/g wet female liver tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine; 34 nmol CO2/h/g wet female ovary tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine; 384 nmol CO2/h/g wet female small intestine tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine; 42 nmol CO2/h/g wet male prostate tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine; 457 nmol CO2/h/g wet male pancreas tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine; 476 nmol CO2/h/g wet female heart tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine; 533 nmol CO2/h/g wet female pancreas tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine; 636 nmol CO2/h/g wet male kidney tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine; 798 nmol CO2/h/g wet male brain, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine; 853 nmol CO2/h/g wet female brain tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine; estrogen ablation or treatment with estradiol does not affect DDC activity; in kidney, DNA and protein levels of DDC are remarkably higher in females than in males (sexual dimorphism); in the small intestine, male mice display higher levels of activity than females (sexual dimorphism); sexual dimorphism of DCC in kidney has physiological relevance in sodium homeostasis; treatment of female mice with testosterone propionate elicits a robust increase in DCC activity in duodenum and jejunum, which is weaker in the ileum; treatment of females with testosterone propionate for short periods of time (24 and 48 h) does not significantly affect renal DCC activity, although levels of mRNA produces a marked decrease in the kidney; treatment of males with the antiandrogen flutamide for short periods of time (24 and 48 h) does not significantly affect renal DCC activity, although levels of mRNA produces a marked increase in the kidney
Mus musculus
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5-hydroxytryptophan
-
693382
Mus musculus
5-hydroxytryptamine + CO2
-
-
-
?
L-Dopa
-
693382
Mus musculus
dopamine + CO2
-
-
-
?
additional information
DDC is involved in the synthesis of dopamine, serotonin and acts as an androgen receptor co-regulator protein
693382
Mus musculus
?
-
-
-
-
additional information
the key step in the formation of the aromatic amines dopamine, epinephrine and norepinephrine is catalyzed by a single enzyme
693382
Mus musculus
?
-
-
-
-
phenylalanine
-
693382
Mus musculus
phenylethylamine + CO2
-
-
-
?
Tryptophan
-
693382
Mus musculus
Tryptamine + CO2
-
-
-
?
tyrosine
-
693382
Mus musculus
tyramine + CO2
-
-
-
?
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
37
-
assay at
Mus musculus
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.2
-
assay at
Mus musculus
Cofactor
Cofactor
Commentary
Organism
Structure
pyridoxal 5'-phosphate
-
Mus musculus
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
pyridoxal 5'-phosphate
-
Mus musculus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
additional information
in castrated male mice, DCC activity decreases in all parts of the small intestine, reaching values similar to those in females
Mus musculus
testosterone propionate
repetitive treatment of female mice with testosterone propionate for 2 weeks elicits a marked decrease in renal DCC activity
Mus musculus
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Na+
inverse correlation between DDC activity and sodium reabsorption in the kidney, confirming the hypothesis that dopamine inhibits sodium absorption
Mus musculus
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
54000
-
predicted from amino acid sequence and determined by Western Blot analysis
Mus musculus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5-hydroxytryptophan
Mus musculus
-
5-hydroxytryptamine + CO2
-
-
?
L-Dopa
Mus musculus
-
dopamine + CO2
-
-
?
additional information
Mus musculus
DDC is involved in the synthesis of dopamine, serotonin and acts as an androgen receptor co-regulator protein
?
-
-
-
additional information
Mus musculus
the key step in the formation of the aromatic amines dopamine, epinephrine and norepinephrine is catalyzed by a single enzyme
?
-
-
-
phenylalanine
Mus musculus
-
phenylethylamine + CO2
-
-
?
Tryptophan
Mus musculus
-
Tryptamine + CO2
-
-
?
tyrosine
Mus musculus
-
tyramine + CO2
-
-
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
adrenal gland
-
Mus musculus
-
brain
-
Mus musculus
-
colon
-
Mus musculus
-
duodenum
sexual dimorphism
Mus musculus
-
heart
-
Mus musculus
-
ileum
sexual dimorphism
Mus musculus
-
jejunum
sexual dimorphism
Mus musculus
-
kidney
sexual dimorphism
Mus musculus
-
liver
-
Mus musculus
-
ovary
-
Mus musculus
-
pancreas
-
Mus musculus
-
prostate
-
Mus musculus
-
skeletal muscle
-
Mus musculus
-
testis
-
Mus musculus
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
additional information
-
2076 nmol CO2/h/g wet female adrenal gland tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine; 2174 nmol CO2/h/g wet male small intestine tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine; 21 nmol CO2/h/g wet female skeletal muscle tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine; 21 nmol CO2/h/g wet male testis tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine; 2322 nmol CO2/h/g wet male adrenal gland tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine; 27 nmol CO2/h/g wet male skeletal muscle tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine; 310 nmol CO2/h/g wet male heart tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine; 3200 nmol CO2/h/g wet male liver tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine; 3247 nmol CO2/h/g wet female kidney tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine; 3410 nmol CO2/h/g wet female liver tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine; 34 nmol CO2/h/g wet female ovary tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine; 384 nmol CO2/h/g wet female small intestine tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine; 42 nmol CO2/h/g wet male prostate tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine; 457 nmol CO2/h/g wet male pancreas tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine; 476 nmol CO2/h/g wet female heart tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine; 533 nmol CO2/h/g wet female pancreas tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine; 636 nmol CO2/h/g wet male kidney tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine; 798 nmol CO2/h/g wet male brain, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine; 853 nmol CO2/h/g wet female brain tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine; estrogen ablation or treatment with estradiol does not affect DDC activity; in kidney, DNA and protein levels of DDC are remarkably higher in females than in males (sexual dimorphism); in the small intestine, male mice display higher levels of activity than females (sexual dimorphism); sexual dimorphism of DCC in kidney has physiological relevance in sodium homeostasis; treatment of female mice with testosterone propionate elicits a robust increase in DCC activity in duodenum and jejunum, which is weaker in the ileum; treatment of females with testosterone propionate for short periods of time (24 and 48 h) does not significantly affect renal DCC activity, although levels of mRNA produces a marked decrease in the kidney; treatment of males with the antiandrogen flutamide for short periods of time (24 and 48 h) does not significantly affect renal DCC activity, although levels of mRNA produces a marked increase in the kidney
Mus musculus
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5-hydroxytryptophan
-
693382
Mus musculus
5-hydroxytryptamine + CO2
-
-
-
?
L-Dopa
-
693382
Mus musculus
dopamine + CO2
-
-
-
?
additional information
DDC is involved in the synthesis of dopamine, serotonin and acts as an androgen receptor co-regulator protein
693382
Mus musculus
?
-
-
-
-
additional information
the key step in the formation of the aromatic amines dopamine, epinephrine and norepinephrine is catalyzed by a single enzyme
693382
Mus musculus
?
-
-
-
-
phenylalanine
-
693382
Mus musculus
phenylethylamine + CO2
-
-
-
?
Tryptophan
-
693382
Mus musculus
Tryptamine + CO2
-
-
-
?
tyrosine
-
693382
Mus musculus
tyramine + CO2
-
-
-
?
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
37
-
assay at
Mus musculus
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.2
-
assay at
Mus musculus
Other publictions for EC 4.1.1.28
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
748545
Portaro
When dysphoria is not a prima ...
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97
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-
1
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8
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4
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1
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1
1
-
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747840
Ren
Heterogenic distribution of a ...
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Front. Integr. Neurosci.
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2
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3
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6
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2
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2
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6
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2
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-
-
-
-
-
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1
1
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743812
Pandey
Fungal endophytes of Catharan ...
Catharanthus roseus
Sci. Rep.
6
26583
2016
-
-
-
-
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-
-
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-
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6
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-
-
-
-
-
-
-
-
1
1
1
1
-
-
748845
Sanchez-Jimenez
Structural and functional ana ...
Homo sapiens
Pharmacol. Res.
114
90-102
2016
-
-
1
-
7
-
3
-
2
-
-
1
-
2
-
-
-
-
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14
-
-
1
2
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1
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1
1
-
7
-
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3
-
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2
-
-
1
-
-
-
-
-
14
-
-
1
2
-
-
-
-
-
-
-
-
1
3
3
1
-
-
726553
Ren
Novel inhibitors of human DOPA ...
Homo sapiens
ACS Chem. Biol.
9
897-903
2014
-
1
-
-
-
-
3
-
-
-
-
-
-
3
-
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2
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1
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2
3
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743890
Liu
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Catharanthus roseus
World J. Microbiol. Biotechnol.
30
175-180
2014
-
1
-
-
-
-
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2
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2
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1
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2
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-
-
-
-
-
-
-
-
1
1
1
1
-
-
746908
Bertoldi
Mammalian dopa decarboxylase ...
Homo sapiens, Rattus norvegicus, Sus scrofa
Arch. Biochem. Biophys.
546
1-7
2014
-
1
3
-
1
-
11
6
-
-
-
7
-
3
-
-
-
3
-
6
-
-
8
3
-
-
-
3
-
-
-
3
1
-
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-
1
3
3
-
1
-
-
11
1
6
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Interaction of human Dopa deca ...
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Biochemical evaluation of the ...
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Expression and functions of do ...
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Shih
Aromatic L-amino acid decarbox ...
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The role of aromatic L-amino a ...
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Torrens-Spence
Biochemical evaluation of the ...
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Molecular cloning and expressi ...
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Zhou
The expression of dopa decarbo ...
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Chakrabarty
Theoretical studies on the pyr ...
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Structural perspective on the ...
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Koyanagi
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Hoefig
Does the aromatic L-amino acid ...
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Daidone
Identification by virtual scre ...
Homo sapiens
PLoS ONE
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Kinetic isotope effects of L-D ...
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Chalatsa
L-Dopa decarboxylase expressio ...
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Chalatsa
Release of membrane-associated ...
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Ishihara
Probing the role of tryptophan ...
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Phytochemistry
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Zhou
A Dopa decarboxylase modulatin ...
Azumapecten farreri
PLoS ONE
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e18596
2011
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Giardina
Open conformation of human DOP ...
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Abnormal glucose metabolism in ...
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Blechingberg
Aromatic L-amino acid decarbox ...
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The roles of striatal serotoni ...
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The timing of administration, ...
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Quantitative expression analys ...
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Duchemin
Aromatic L-amino acid decarbox ...
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693955
Moreira-Rodrigues
Renal dopaminergic system acti ...
Rattus norvegicus
Life Sci.
84
409-414
2009
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1
3
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2
4
-
1
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694106
Fujimori
Characterization of the regula ...
Oryzias latipes
Mol. Biotechnol.
41
224-235
2009
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-
1
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2
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2
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15
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2
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1
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15
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2
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701921
Bertoldi
Multiple roles of the active s ...
Homo sapiens
Arch. Biochem. Biophys.
488
130-139
2009
-
-
1
-
1
-
1
5
-
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1
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1
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1
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5
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1
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1
1
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1
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1
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5
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1
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1
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5
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704020
Hiruma
The molecular mechanisms of cu ...
Manduca sexta
Insect Biochem. Mol. Biol.
39
245-253
2009
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2
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2
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-
1
-
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-
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2
1
1
2
-
-
704084
da Silva
Differential immunodetection o ...
Didelphis aurita, Gallus gallus
Int. J. Dev. Neurosci.
27
469-476
2009
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3
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2
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704491
Arakane
Molecular and functional analy ...
Tribolium castaneum
J. Biol. Chem.
284
16584-16594
2009
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5
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1
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1
1
-
-
-
704803
Kitahama
Aromatic L-amino acid decarbox ...
Homo sapiens
J. Chem. Neuroanat.
38
130-140
2009
-
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2
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4
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8
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2
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1
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1
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2
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8
-
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2
-
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-
705269
Kokkinou
The U937 macrophage cell line ...
Homo sapiens
J. Neuroimmunol.
216
51-58
2009
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2
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2
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1
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2
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1
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3
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1
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-
705756
Allen
A new perspective on the treat ...
Homo sapiens
Mol. Genet. Metab.
97
6-14
2009
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3
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6
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3
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2
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6
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1
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1
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3
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6
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2
-
-
6
-
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1
1
-
-
-
705914
Giegling
Tyrosine hydroxylase and DOPA ...
Homo sapiens
Neuropsychobiology
59
23-27
2009
-
1
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1
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1
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1
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1
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1
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1
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684439
Campos-Tamayo
Vindoline formation in shoot c ...
Catharanthus roseus
Ann. Bot.
102
409-415
2008
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-
-
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2
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1
5
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1
5
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1
1
-
-
-
690973
Bertoldi
Insights into the mechanism of ...
Sus scrofa
Biochemistry
47
7187-7195
2008
-
-
1
-
2
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3
2
-
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-
2
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1
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1
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1
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2
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4
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1
2
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1
1
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2
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3
2
2
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2
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1
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1
-
2
-
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-
-
4
-
-
-
-
-
-
-
-
-
-
691469
Kokkinou
Expression of enzymatically ac ...
Homo sapiens
Blood Cells Mol. Dis.
42
92-98
2008
-
-
1
-
-
-
-
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2
-
3
2
-
2
-
-
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-
-
6
3
-
2
1
1
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-
1
-
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-
1
1
-
-
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2
-
3
2
-
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-
-
6
3
-
2
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
691846
Avgeris
Expression analysis and clinic ...
Homo sapiens
Clin. Biochem.
41
1140-1149
2008
1
1
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-
-
-
-
-
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3
-
2
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3
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3
1
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1
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1
1
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1
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3
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3
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-
3
1
-
-
-
-
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-
-
-
-
-
-
-
-
-
691888
Hadjiconstantinou
Enhancing aromatic L-amino aci ...
Homo sapiens, Mus musculus, Rattus norvegicus
CNS Neurosci. Ther.
14
340-351
2008
32
3
-
-
-
-
11
-
-
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-
3
-
4
-
3
-
-
-
14
3
-
3
-
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-
-
-
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-
3
-
-
-
32
3
-
3
-
-
-
-
11
-
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-
3
-
-
3
-
-
14
3
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
691906
Paskewitz
Silencing the genes for dopa d ...
Anopheles gambiae
Comp. Biochem. Physiol. B
150
403-408
2008
-
-
1
-
-
-
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4
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3
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4
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2
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4
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4
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-
-
-
-
-
-
-
-
691987
Ito
Aromatic L-amino acid decarbox ...
Homo sapiens
Dev. Med. Child Neurol.
50
876-878
2008
-
1
-
-
-
-
-
-
-
-
-
3
-
2
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3
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1
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1
-
1
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3
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-
-
3
-
-
-
-
-
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-
-
-
-
-
-
-
-
692189
Lee
Aromatic l-amino acid decarbox ...
Homo sapiens
Eur. J. Paediatr. Neurol.
13
135-140
2008
-
-
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4
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2
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1
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4
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4
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1
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
692194
Jin
Induction of dopamine biosynth ...
Rattus norvegicus
Eur. J. Pharmacol.
591
88-95
2008
1
-
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-
-
-
2
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1
-
1
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1
2
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1
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1
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2
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1
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1
2
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
692593
Sideri
Innate immunity in insects: su ...
Ceratitis capitata
Immunology
123
528-537
2008
-
-
-
-
-
-
3
-
-
-
-
4
-
4
-
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4
1
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4
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1
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1
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3
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4
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4
1
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
692661
Traeger
mRNAs of tyrosine hydroxylase ...
Homo sapiens
Int. J. Cancer
123
2849-2855
2008
1
1
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-
-
-
-
-
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2
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2
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-
3
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2
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1
1
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2
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3
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
693374
Hofto
The importance of aromatic-typ ...
Homo sapiens
J. Comput. Chem.
30
1111-1115
2008
-
-
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-
1
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3
-
1
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4
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1
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3
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-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
693382
Lopez-Contreras
Opposite sexual dimorphism of ...
Mus musculus
J. Endocrinol.
196
615-624
2008
-
-
-
-
-
-
2
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-
1
1
7
-
3
-
-
-
-
-
16
1
-
7
-
1
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
-
-
2
-
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-
1
1
7
-
-
-
-
-
16
1
-
7
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
694156
Menheniott
Genomic imprinting of Dopa dec ...
Mus musculus
Mol. Cell. Biol.
28
386-396
2008
-
-
-
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-
1
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2
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2
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2
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2
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1
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2
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2
-
-
2
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
694157
Davis
A member of the p38 mitogen-ac ...
Drosophila melanogaster
Mol. Cell. Biol.
28
4883-4895
2008
1
-
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4
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5
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3
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4
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1
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4
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3
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
694283
Cunningham
Biodistribution of adeno-assoc ...
Homo sapiens
Mol. Ther.
16
1267-1275
2008
1
1
1
-
-
-
-
-
-
-
-
1
-
6
-
-
-
-
-
-
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-
1
-
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-
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-
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-
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-
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-
1
1
1
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1
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-
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-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
694353
Buck
Intrastriatal inhibition of ar ...
Rattus norvegicus
Neurobiol. Dis.
29
210-220
2008
-
-
-
-
-
-
1
-
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-
1
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2
-
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-
1
-
-
1
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-
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1
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1
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-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
694362
Vassiliou
Detection, purification and id ...
Mus musculus
Neurochem. Res.
34
1089-1100
2008
-
1
-
-
-
-
3
-
-
-
-
2
-
2
-
-
-
-
-
2
-
-
2
-
1
-
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-
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1
2
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-
-
1
-
1
-
-
-
-
3
2
-
-
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-
2
-
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-
-
2
-
-
2
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
694368
Eberling
Results from a phase I safety ...
Homo sapiens
Neurology
70
1980-1983
2008
-
1
1
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-
-
-
-
-
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1
-
3
-
-
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1
1
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1
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1
1
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-
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1
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1
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
677950
Bratland
Epitope mapping of human aroma ...
Homo sapiens
Biochem. Biophys. Res. Commun.
353
692-698
2007
-
-
1
-
1
-
-
-
-
-
-
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2
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1
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-
1
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2
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1
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1
1
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1
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-
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1
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
678981
Kitahama
Localization of L-DOPA uptake ...
Felis catus
Brain Res.
1167
56-70
2007
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
5
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1
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5
-
-
1
-
-
-
-
-
-
-
-
-
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680070
Seta
Immunohistochemical localizati ...
Mus musculus
Histochem. Cell Biol.
127
415-422
2007
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-
-
-
-
-
-
-
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4
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4
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1
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4
-
-
1
-
-
-
-
-
-
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-
-
-
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-
-
-
-
680090
Wafa
Comprehensive expression analy ...
Homo sapiens
Hum. Pathol.
38
161-170
2007
-
-
-
-
-
-
-
-
-
-
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1
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1
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1
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2
-
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681067
Candeloro
Mapping of human autoantibody ...
Homo sapiens
J. Clin. Endocrinol. Metab.
92
1096-1105
2007
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-
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3
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1
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1
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-
-
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-
-
-
-
-
-
681865
Margiotti
Androgen-regulated genes diffe ...
Homo sapiens
Mol. Cancer
6
38
2007
-
-
1
-
-
-
-
-
1
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2
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2
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1
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1
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2
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-
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-
681948
Verbeek
Aromatic L-amino acid decarbox ...
Homo sapiens
Mol. Genet. Metab.
90
363-369
2007
-
-
-
-
-
-
6
2
-
-
-
-
-
2
-
-
-
-
-
1
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-
2
-
-
-
-
-
1
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-
1
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-
-
-
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1
6
-
2
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-
-
1
-
-
2
-
-
-
-
-
1
-
-
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-
666154
Neff
Clozapine modulates aromatic L ...
Mus musculus
J. Pharmacol. Exp. Ther.
317
480-487
2006
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2
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2
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1
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1
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1
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2
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-
2
-
-
-
-
-
-
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-
-
-
-
-
-
-
-
677584
Hodgetts
Dopa decarboxylase: a model ge ...
Aedes aegypti, Bombyx mori, Ceratitis capitata, Drosophila melanogaster, Mamestra brassicae, Manduca sexta, Mythimna separata, Tenebrio molitor
Annu. Rev. Entomol.
51
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2006
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5
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5
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16
-
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5
-
5
-
-
16
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
679140
Weihe
Three types of tyrosine hydrox ...
Macaca mulatta
Cell. Mol. Neurobiol.
26
659-678
2006
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-
-
-
-
-
-
-
1
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4
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9
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1
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1
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9
-
-
1
-
-
-
-
-
-
-
-
-
-
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681181
Uccella
Histidine decarboxylase, DOPA ...
Homo sapiens
J. Histochem. Cytochem.
54
863-875
2006
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-
-
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1
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1
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6
-
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2
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1
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1
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1
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6
-
-
2
-
-
-
-
-
-
-
-
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-
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681537
Tehranian
Alpha-synuclein inhibits aroma ...
Rattus norvegicus
J. Neurochem.
99
1188-1196
2006
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-
1
-
1
-
1
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1
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-
1
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-
1
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1
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-
1
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1
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1
-
-
1
-
-
-
-
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-
-
-
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-
-
-
-
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-
682538
Tieman
Tomato aromatic amino acid dec ...
Solanum lycopersicum
Proc. Natl. Acad. Sci. USA
103
8287-8292
2006
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1
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1
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2
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1
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-
1
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4
-
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-
1
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-
2
-
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1
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2
-
2
-
-
4
-
-
-
-
1
-
-
-
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-
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664473
DeJesus
Aromatic L-amino acid decarbox ...
Macaca mulatta
Brain Res.
1054
55-60
2005
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-
-
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1
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1
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-
2
-
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1
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1
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1
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-
2
-
-
1
-
-
-
-
-
-
-
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666118
Doroudchi
Adeno-associated virus-mediate ...
Homo sapiens
J. Neurochem.
93
634-640
2005
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1
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6
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1
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2
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1
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1
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1
-
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2
-
-
-
-
-
-
-
-
-
-
-
-
-
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663634
Chang
Levodopa-responsive aromatic L ...
Homo sapiens
Ann. Neurol.
55
435-438
2004
-
-
-
-
-
-
-
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1
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1
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-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
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664457
Hare
Function and evolution of the ...
Caenorhabditis elegans
BMC Evol. Biol.
4
24
2004
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-
-
-
-
-
-
-
-
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6
-
-
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1
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-
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-
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-
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-
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-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
665125
Sun
Coexpression of tyrosine hydro ...
Homo sapiens
Hum. Gene Ther.
15
1177-1196
2004
-
1
1
-
-
-
-
-
2
-
-
-
-
3
-
-
-
-
-
-
-
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-
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-
1
1
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2
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-
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-
-
-
-
-
-
-
-
-
-
-
-
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665420
Matsuda
Instability of the apo form of ...
Rattus norvegicus
J. Biochem.
135
33-42
2004
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-
-
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-
1
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3
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1
-
-
1
-
-
1
-
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-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
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1
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
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-
-
-
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666447
Vassilacopoulou
Identification and characteriz ...
Homo sapiens
Neurochem. Res.
29
1817-1823
2004
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-
1
-
-
-
-
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2
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-
-
1
-
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-
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-
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-
-
1
-
-
-
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-
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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666457
Brust
Developmental changes in the a ...
Sus scrofa
Neurosci. Lett.
364
159-163
2004
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-
-
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-
-
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3
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2
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2
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
666464
Kubovcakova
Identification of the aromatic ...
Mus musculus, Mus musculus C57BL / 129SV
Neuroscience
126
375-380
2004
-
-
-
-
-
-
-
-
-
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3
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-
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10
-
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-
-
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-
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-
-
-
-
-
-
-
-
-
-
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-
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-
-
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-
-
10
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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650410
Bertoldi
Reaction and substrate specifi ...
Sus scrofa
Biochim. Biophys. Acta
1647
42-47
2003
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1
1
-
-
-
-
-
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1
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2
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1
-
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8
1
-
-
-
-
-
-
-
1
-
-
-
-
1
1
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
8
1
-
-
-
-
-
-
-
-
-
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-
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653356
Siaterli
Cloning and expression of huma ...
Homo sapiens
Neurochem. Res.
28
797-803
2003
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-
1
-
-
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-
1
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2
1
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2
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1
-
-
1
1
-
2
1
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
1
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-
2
1
-
-
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1
-
1
1
-
2
1
-
-
-
-
-
-
-
-
-
-
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-
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649601
Borri Voltattorni
Behavior of fluorinated analog ...
Sus scrofa
Biochem. Biophys. Res. Commun.
295
107-111
2002
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1
1
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-
-
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4
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1
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1
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1
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-
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7
-
-
-
-
5
-
-
-
1
-
-
-
-
1
1
1
-
-
-
-
-
-
4
-
-
-
1
-
-
-
1
-
-
-
-
7
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
650436
Poulikakos
-
A membrane-associated form of ...
Ceratitis capitata
Biogenic Amines
17
15-24
2002
-
-
-
-
-
-
-
-
2
-
1
1
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
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-
1
-
-
-
-
-
-
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2
-
1
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
651417
Ishida
Circadian rhythm of aromatic L ...
Rattus norvegicus
Genes Cells
7
447-459
2002
-
-
1
-
-
-
-
-
1
-
-
1
-
2
-
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-
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1
-
-
3
-
-
-
-
-
-
-
-
-
-
-
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-
-
1
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-
-
-
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-
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-
1
-
-
1
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-
-
1
-
-
3
-
-
-
-
-
-
-
-
-
-
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-
-
-
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653346
Nagy
Role of tyrosine, DOPA and dec ...
Locusta migratoria
Neurochem. Int.
41
9-16
2002
1
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-
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5
3
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1
1
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1
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5
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3
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1
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1
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1
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5
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3
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1
1
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1
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-
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5
-
-
-
-
-
3
-
-
-
-
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653528
Di Fiore
Targeting tryptophan decarboxy ...
Nicotiana tabacum
Plant Physiol.
129
1160-1169
2002
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1
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-
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3
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2
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1
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3
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1
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-
-
-
-
-
2
-
-
-
-
-
-
-
-
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650450
Tang
Identification and characteriz ...
Dirofilaria immitis
Biol. Chem.
382
115-122
2001
1
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3
3
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1
1
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3
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1
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6
1
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1
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1
-
1
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1
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3
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3
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1
1
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1
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-
6
1
-
-
-
-
-
-
-
1
-
-
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653352
Poulikakos
L-DOPA decarboxylase associati ...
Mus musculus
Neurochem. Res.
26
479-485
2001
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1
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-
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3
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1
1
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1
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-
2
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-
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-
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1
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-
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1
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1
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-
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-
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3
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1
1
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1
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2
-
-
-
-
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649696
Bertoldi
-
Reaction of dopa decarboxylase ...
Sus scrofa
Biochem. J.
352
533-538
2000
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1
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3
1
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8
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1
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1
1
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-
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4
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1
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1
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1
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3
1
-
-
-
8
-
-
-
-
-
-
-
-
-
-
650868
Husebye
Inhibition of aromatic L-amino ...
Rattus norvegicus
Clin. Exp. Immunol.
120
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2000
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-
1
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1
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1
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1
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1
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-
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2
1
-
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-
-
1
-
-
-
-
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-
-
651068
Kim
Bacterial-injection-induced sy ...
Tenebrio molitor
Eur. J. Biochem.
267
2599-2608
2000
1
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1
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-
-
-
2
-
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2
1
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1
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1
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1
1
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-
-
2
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
653366
Mura
Striatal cells containing arom ...
Rattus norvegicus
Neuroscience
98
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2000
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-
-
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2
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1
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2
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1
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2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
653443
Facchini
Plant aromatic L-amino acid de ...
Camptotheca acuminata, Catharanthus roseus, Cinchona calisaya, Cinchona officinalis, Drosophila melanogaster, Homo sapiens, Solanum lycopersicum, Sus scrofa
Phytochemistry
54
121-138
2000
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8
8
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2
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7
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8
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29
1
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-
-
-
-
-
8
1
1
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8
8
8
-
-
-
-
2
1
-
-
-
2
7
-
-
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1
-
-
-
-
29
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
653288
Niedens
-
First fungal aromatic L-amino ...
no activity in Penicillium raistrickii, Penicillium raistrickii, Penicillium raistrickii H10BA2
Mycologia
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619-626
1999
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3
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1
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11
1
1
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-
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1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
3
-
-
1
2
-
-
-
1
-
-
1
-
11
1
1
-
-
-
1
-
-
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-
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-
-
744008
Sangwan
Direct fluorometry of phase-e ...
Catharanthus roseus
Anal. Biochem.
255
39-46
1998
-
-
-
-
-
-
-
-
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1
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1
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1
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1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4231
Jebai
Expression, purification, and ...
Rattus norvegicus
Protein Expr. Purif.
11
185-194
1997
-
-
1
-
-
-
-
2
-
-
-
-
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3
-
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1
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-
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1
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2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
1
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
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-
-
-
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4229
Bossinakou
Purification and characterizat ...
Ceratitis capitata
Comp. Biochem. Physiol. B
113
213-220
1996
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-
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-
-
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6
2
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5
1
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3
1
-
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-
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-
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-
-
-
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-
-
-
-
-
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6
-
2
-
-
2
-
-
-
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1
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5
1
-
3
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4222
Zhu
Aromatic L-amino acid decarbox ...
Bos taurus, Cavia porcellus, Homo sapiens, Rattus norvegicus, Sus scrofa, Xenopus laevis
Gen. Pharmacol.
26
681-696
1995
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17
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12
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7
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5
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-
-
17
-
-
12
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4223
Facchini
Expression in Escherichia coli ...
Cytisus scoparius, Hordeum vulgare, Papaver somniferum, Petroselinum crispum, Sanguinaria canadensis, Syringa vulgaris, Thalictrum rugosum
Phytochemistry
38
1119-1126
1995
-
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1
-
-
-
-
4
-
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-
-
-
7
-
-
-
-
-
-
-
-
8
-
-
-
-
-
1
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
8
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
4230
Dominici
Modified purification of L-aro ...
Sus scrofa
Protein Expr. Purif.
4
345-347
1993
-
-
-
-
-
-
-
-
-
-
-
1
-
2
-
-
1
-
-
2
1
-
1
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-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
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-
-
-
-
-
-
1
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-
-
1
-
2
1
-
1
-
-
-
-
-
-
-
-
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-
-
-
-
-
-
4224
Dluzen
The aromatic amino acid decarb ...
Rattus norvegicus
Neuropharmacology
31
1223-1229
1992
-
-
-
-
-
-
-
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-
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2
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3
-
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-
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-
-
-
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-
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-
-
-
-
-
-
-
-
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-
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-
-
-
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-
-
3
-
-
-
-
-
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-
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-
-
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-
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4225
Nasrin
Comparison and characteristics ...
Bos taurus, Homo sapiens
Biochim. Biophys. Acta
1118
318-322
1992
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1
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4
1
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-
-
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1
-
4
1
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-
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-
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-
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-
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4232
Park
Characterization of bovine aro ...
Bos taurus
Mol. Brain Res.
16
232-238
1992
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1
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1
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1
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1
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1
1
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2
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1
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1
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4226
Sumi
Characterization of recombinan ...
Homo sapiens
J. Neurochem.
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1075-1078
1990
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4227
Siow
Purification of dopa decarboxy ...
Bos taurus
Mol. Cell. Biochem.
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121-131
1990
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1
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4228
Mappouras
Purification and characterizat ...
Homo sapiens
Mol. Cell. Biochem.
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147-156
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3
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1
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4234
Borresen
Purification and characterizat ...
Sus scrofa
Biochim. Biophys. Acta
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1989
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1
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1
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1
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4209
Groen
Evidence for PQQ as cofactor i ...
Sus scrofa
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237
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1988
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1
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1
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1
-
1
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1
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4219
Nishigaki
Purification of aromatic L-ami ...
Bos taurus
Biochem. J.
252
331-335
1988
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4
2
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1
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4
2
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1
1
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4235
Tancini
Limited tryptic proteolysis of ...
Sus scrofa
Arch. Biochem. Biophys.
260
569-576
1988
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2
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745120
Chaudhuri
Tryptophan hydroxylase and ar ...
Ascaris suum
Int. J. Parasitol.
18
341-346
1988
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2
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2
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4208
Nakazawa
-
Inhibition of aromatic L-amino ...
Micrococcus percitreus, Micrococcus percitreus AJ1065
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2531-2537
1987
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11
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11
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2
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4217
Ando-Yamamoto
Purification of L-DOPA decarbo ...
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J. Biochem.
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405-414
1987
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1
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1
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3
1
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1
1
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-
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1
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4218
Voltattorni
Aromatic-L-amino acid decarbox ...
Sus scrofa
Methods Enzymol.
142
179-187
1987
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2
13
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1
1
1
5
1
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1
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4220
Dominici
Purification and characterizat ...
Rattus norvegicus
Eur. J. Biochem.
169
209-213
1987
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1
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2
1
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1
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1
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1
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1
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743978
Nakazawa
-
Inhibition of aromatic L-amin ...
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51
2531-2537
1987
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2
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4207
Lindström
Aromatic-L-amino-acid decarbox ...
Mus musculus
Biochim. Biophys. Acta
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276-281
1986
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Jung
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Substrates and Inhibitors of a ...
Mammalia
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Nakazawa
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Decarboxylation reaction of a ...
Micrococcus percitreus, Micrococcus percitreus AJ 1065
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-
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2
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-
-
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1
1
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1
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-
4
1
1
-
-
-
2
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-
2
-
-
-
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-
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-
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4206
Nakazawa
-
Cofactor requirements of const ...
Micrococcus percitreus
Agric. Biol. Chem.
47
1605-1609
1983
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1
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1
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1
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1
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-
1
-
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-
-
-
-
4216
Nakazawa
-
Aromatic L-amino acid decarbox ...
Micrococcus percitreus
Agric. Biol. Chem.
45
2543-2552
1981
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-
-
1
-
-
-
4
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-
3
-
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1
-
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1
-
-
-
1
1
19
1
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4
-
1
-
6
-
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-
-
-
-
1
-
-
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4
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3
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1
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-
1
1
19
1
-
-
4
-
1
-
6
-
-
-
-
-
-
-
743976
Nakazawa
-
Aromatic L-amino acid decarbo ...
Micrococcus percitreus, Micrococcus percitreus AJ 1065
Agric. Biol. Chem.
45
2543-2552
1981
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-
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1
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1
2
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5
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1
-
-
-
-
1
26
1
-
-
1
-
1
-
1
1
-
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-
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-
1
-
-
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1
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1
2
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1
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-
-
1
26
1
-
-
1
-
1
-
1
-
-
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-
-
-
744252
Barboni
An abnormal reaction occurrin ...
Sus scrofa
Biochem. Biophys. Res. Commun.
99
576-583
1981
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-
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1
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1
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3
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1
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1
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1
-
-
3
-
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-
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4205
Minelli
Reactions of DOPA (3,4-dihydro ...
Sus scrofa
Biochem. J.
183
361-368
1979
-
-
-
-
-
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1
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1
-
1
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1
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1
-
-
1
-
-
-
-
-
-
-
-
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-
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-
-
-
-
4214
Voltattorni
Purification and characterizat ...
Sus scrofa
Eur. J. Biochem.
93
181-188
1979
-
-
-
-
-
-
-
-
-
-
-
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-
2
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-
1
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-
1
2
1
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1
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-
1
-
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-
1
-
1
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4215
Bouchard
Biochemical properties and kin ...
Felis catus
Can. J. Biochem.
57
1014-1018
1979
-
-
-
-
-
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-
1
-
-
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2
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-
-
5
-
-
2
-
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3
-
-
1
-
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-
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-
1
-
-
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1
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-
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5
-
-
2
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
4212
Clark
-
Dopa decarboxylase from Drosop ...
Drosophila melanogaster
Mol. Gen. Genet.
162
287-297
1978
-
-
-
-
-
1
5
2
-
-
3
-
-
1
-
-
1
-
-
1
1
1
2
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
1
-
5
-
2
-
-
3
-
-
-
-
1
-
1
1
1
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4213
Srinivasan
Substrate specificity and othe ...
Cavia porcellus
Biochim. Biophys. Acta
526
597-604
1978
-
-
-
-
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-
1
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-
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2
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1
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-
2
1
-
8
-
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-
1
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
2
1
-
8
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4204
Bender
Aromatic amino acid decarboxyl ...
Rattus norvegicus
Biochem. Soc. Trans.
5
1353-1356
1977
-
-
-
-
-
-
4
-
-
-
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1
-
1
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-
1
-
-
1
-
-
3
-
-
-
-
-
-
-
-
-
-
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-
4
-
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-
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-
1
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1
-
1
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4211
Fragoulis
Purification and characteristi ...
Calliphora vicina
Arch. Biochem. Biophys.
168
15-25
1975
-
-
-
-
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4
1
-
2
3
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-
1
-
-
-
-
-
1
1
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
1
-
2
3
-
-
-
-
-
-
1
1
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4202
Nakazawa
Constitutive aromatic L-amino ...
Micrococcus percitreus
Biochem. Biophys. Res. Commun.
61
75-82
1974
-
-
-
1
-
-
-
1
-
-
1
1
-
2
-
-
1
-
-
-
1
-
4
-
-
-
-
-
1
1
-
1
-
-
-
-
-
-
1
1
-
-
-
-
-
1
-
-
1
1
-
-
-
1
-
-
1
-
4
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
744251
Nakazawa
Constitutive aromatic L-amino ...
Micrococcus percitreus, Micrococcus percitreus AJ 1065
Biochem. Biophys. Res. Commun.
61
75-82
1974
-
-
-
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-
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1
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1
2
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6
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1
-
-
-
-
-
8
-
-
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-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
1
2
-
-
-
1
-
-
-
-
8
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
4200
Christenson
On the identity of DOPA decarb ...
Oryctolagus cuniculus, Rattus norvegicus, Sus scrofa
Proc. Natl. Acad. Sci. USA
69
343-347
1972
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-
-
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-
3
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5
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6
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5
-
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6
-
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-
-
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-
-
-
-
-
-
-
-
-
4201
Tocher
-
DOPA decarboxylase in Cytisus ...
Cytisus scoparius
Phytochemistry
11
1661-1667
1972
1
-
-
-
-
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13
-
-
-
-
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-
1
-
-
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-
4
-
-
3
-
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-
-
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-
-
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-
1
-
-
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-
-
-
-
13
-
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-
-
-
-
-
-
-
-
4
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4203
Baxter
-
Partial purification and some ...
Phalaris aquatica
Phytochemistry
11
2763-2766
1972
-
-
-
-
-
-
5
-
-
-
-
1
-
1
-
-
1
-
-
1
-
-
5
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
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-
5
-
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-
1
-
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1
-
1
-
-
5
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
4210
Lovenberg
-
Aromatic L-amino acid decarbox ...
Cavia porcellus
Methods Enzymol.
17B
652-656
1971
2
-
-
-
-
-
4
6
-
-
-
-
-
1
-
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1
-
-
1
1
1
9
-
-
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-
1
-
-
-
-
-
-
2
-
-
-
-
-
-
-
4
-
6
-
-
-
-
-
-
-
1
-
1
1
1
9
-
-
-
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-
1
-
-
-
-
-
-
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-
-