Any feedback?
Literature summary for 4.1.1.28 extracted from
- The importance of aromatic-type interactions in serotonin synthesis: Protein-ligand interactionsin tryptophan hydroxylase and aromatic amino acid decarboxylase (2008), J. Comput. Chem., 30, 1111-1115.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | Model chemistry by second-order Moller-Plessett perturbation theory calculations, phenylalanine in position 103 is replaced by all native amino acids. The mutant residues which conserve an aromatic side chain (tyrosine and tryptophan) retain near 100% interaction energy with the carbidopa, and thus most likely retain full protein function. Arginine has an interaction energy of 555% of the wild-type. This is due to the fact that the long, polar side chain is able to find a geometry where a hydrogen bond is being made with the hydroxyl group of the carbidopa. The small side chains are not close enough to the carbidopa to have a large deal of dispersion/induction interactions. Residues are arranged by the size of the side chain, and with a few exception, the interaction energy generally increases with size of the side chain. Glycine, alanine, serine, threonine, and histidine all fall below the above mentioned 20% threshold and would likely cause a loss of protein function. Serine contains a polar side chain and histidine has pi-electrons, yet these residues are too small and too far removed to have strong interactions. | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5-Hydroxytryptophan | Homo sapiens | The biosynthesis of serotonin requires aromatic substrates to be bound in the active sites of the enzymes tryptophan hydroxylase and aromatic amino acid decarboxylase | Serotonin + CO2 | - |
? |  |
| L-Dopa | Homo sapiens | - |
dopamine + CO2 | - |
? | |
| additional information | Homo sapiens | Mutations that decrease substrate binding can result in a decrease in serotonin production and thus can lead to depression and related disorders | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5-Hydroxytryptophan | The biosynthesis of serotonin requires aromatic substrates to be bound in the active sites of the enzymes tryptophan hydroxylase and aromatic amino acid decarboxylase | Homo sapiens | Serotonin + CO2 | - |
? | |
| carbidopa | interaction of carbidopa with the Phe103 residue of the enzyme, the residue forms a displaced sandwich-type sigma-complex with carbidopa | Homo sapiens | ? | - |
? | |
| L-Dopa | - |
Homo sapiens | dopamine + CO2 | - |
? | |
| additional information | Mutations that decrease substrate binding can result in a decrease in serotonin production and thus can lead to depression and related disorders | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AACD | - |
Homo sapiens |
| Aromatic amino acid decarboxylase | - |
Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
