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Literature summary for 4.1.1.28 extracted from

  • Traeger, C.; Vernby, A.; Kullman, A.; Ora, I.; Kogner, P.; Kagedal, B.
    mRNAs of tyrosine hydroxylase and dopa decarboxylase but not of GD2 synthase are specific for neuroblastoma minimal disease and predicts outcome for children with high-risk disease when measured at diagnosis (2008), Int. J. Cancer, 123, 2849-2855.
    View publication on PubMed
Search for more literature for 4.1.1.28

Activating Compound

Activating Compound Comment Organism Structure
additional information high expression of DDC in blood and bone marrow corresponds to metastatic neuroblastoma at diagnosis, residual disease, and poor outcome Homo sapiens

Application

Application Comment Organism
medicine diagnosis of neuroblastoma, both tyrosine hydroxylase mRNA and DDC mRNA could be useful for stratifying patients into different treatment groups in future clinical trials. Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-Dopa Homo sapiens
-
 dopamine + CO2
-
 ?
additional information Homo sapiens tyrosine hydroxylase mRNA and DDC mRNA in plasma of children with neuroblastoma are highly correlated ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood from children with neuroblastoma Homo sapiens
-
bone marrow rom the posterior iliac crest of children with neuroblastoma Homo sapiens
-
neuroblastoma cell line IMR 32, CHP-212, SH-SY5Y, SK-N-SH, SK-N-FI, SK-N-AS, SK-N-BE(2) and SK-N-DZ Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Dopa
-
 Homo sapiens dopamine + CO2
-
 ?
additional information tyrosine hydroxylase mRNA and DDC mRNA in plasma of children with neuroblastoma are highly correlated Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
DDC
-
 Homo sapiens
DOPA decarboxylase
-
 Homo sapiens