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Literature summary for 4.1.1.28 extracted from

  • Sideri, M.; Tsakas, S.; Markoutsa, E.; Lampropoulou, M.; Marmaras, V.J.
    Innate immunity in insects: surface-associated dopa decarboxylase-dependent pathways regulate phagocytosis, nodulation and melanization in medfly haemocytes (2008), Immunology, 123, 528-537.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.1.1.28

Inhibitors

Inhibitors Comment Organism Structure
benzerazide Escherichia coli phagocytosis is blocked by benzerazide, revealing the involvement of Ddc activity in phagocytosis Ceratitis capitata
carbidopa Escherichia coli phagocytosis is blocked by carbidopa, revealing the involvement of Ddc activity in phagocytosis Ceratitis capitata
additional information decrease of Escherichia coli phagocytosis in the presence of Ddc small interfering RNA of about 30%, compared with the controls; Escherichia coli phagocytosis is blocked by small interfering RNA for Ddc and antibodies against Ddc, revealing the involvement of Ddc activity in phagocytosis. Haemocyte-surface-associated Ddc is decreased by about 90% in haemocytes transfected with Ddc siRNA, compared to the control experiment; when haemocytes are pretreated with anti-Ddc instead of Ddc small interfering RNA before challenge with Escherichia coli, a greater decrease of Escherichia coli phagocytosis (about 60%) is observed, compared with the siRNA results (30%) Ceratitis capitata

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5-hydroxy-L-tryptophan Ceratitis capitata
-
 serotonin + CO2
-
 ?
L-Dopa Ceratitis capitata
-
 dopamine + CO2
-
 ?
additional information Ceratitis capitata Ddc activities are key regulatory components for haemocyte aggregation and melanization in the presence of bacteria ?
-
 ?
additional information Ceratitis capitata Ddc is involved in wound healing, parasite defense, cuticle hardening, melanization and in the behavior of insects ?
-
 ?

Organism

Organism UniProt Comment Textmining
Ceratitis capitata O45216 medfly
-

Source Tissue

Source Tissue Comment Organism Textmining
epidermal cell
-
 Ceratitis capitata
-
hemocyte haemolymph from third instar larvae is collected and centrifuged and the sedimented haemocytes are used, surface-associated Ddc and inside localization, changes in the level of haemocyte-surface Ddc are observed during larval development, with a peak in the white pupae Ceratitis capitata
-
neuron
-
 Ceratitis capitata
-
ovary
-
 Ceratitis capitata
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 Ddc activity is required for Escherichia coli phagocytosis Ceratitis capitata
additional information
-
 phagocytosis, melanization and nodulation in insects depending on dopa decarboxylase activity, because antibodies against Ddc and inhibitors of Ddc activity prevent haemocyte aggregation and melanization in the presence of excess Escherichia coli Ceratitis capitata

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-hydroxy-L-tryptophan
-
 Ceratitis capitata serotonin + CO2
-
 ?
L-Dopa
-
 Ceratitis capitata dopamine + CO2
-
 ?
additional information Ddc activities are key regulatory components for haemocyte aggregation and melanization in the presence of bacteria Ceratitis capitata ?
-
 ?
additional information Ddc is involved in wound healing, parasite defense, cuticle hardening, melanization and in the behavior of insects Ceratitis capitata ?
-
 ?

Synonyms

Synonyms Comment Organism
DDC
-
 Ceratitis capitata
DOPA decarboxylase
-
 Ceratitis capitata

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Ceratitis capitata