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Literature summary for 4.1.1.28 extracted from

  • Neff, N.H.; Wemlinger, T.A.; Duchemin, A.M.; Hadjiconstantinou, M.
    Clozapine modulates aromatic L-amino acid decarboxylase activity in mouse striatum (2006), J. Pharmacol. Exp. Ther., 317, 480-487.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-Dopa Mus musculus clozapine modulates AAAD activity in striatum and enhances exogenous L-DOPA decarboxylation in intact mice and mice lesioned with1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Kinetic analysis of AAAD at 1 h showed an increase in the apparent Vmax for both the substrate L-DOPA and the cofactor pyridoxal-5'-phosphate with no changes for Km. Dopamine D4 and 5-HT2A and 5-HT1A antagonists also increase AAAD activity in striatum dopamine + CO2
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Organism

Organism UniProt Comment Textmining
Mus musculus
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male Swiss-Webster
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Source Tissue

Source Tissue Comment Organism Textmining
corpus striatum clozapine modulates AAAD activity in striatum and enhances exogenous L-DOPA decarboxylation in intact mice and mice lesioned with1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Kinetic analysis of AAAD at 1 h showed an increase in the apparent Vmax for both the substrate L-DOPA and the cofactor pyridoxal-5'-phosphate with no changes for Km. Dopamine D4 and 5-HT2A and 5-HT1A antagonists also increase AAAD activity in striatum Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3,4-Dihydroxyphenylalanine i.e. L-dopa Mus musculus Dopamine + CO2
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L-Dopa clozapine modulates AAAD activity in striatum and enhances exogenous L-DOPA decarboxylation in intact mice and mice lesioned with1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Kinetic analysis of AAAD at 1 h showed an increase in the apparent Vmax for both the substrate L-DOPA and the cofactor pyridoxal-5'-phosphate with no changes for Km. Dopamine D4 and 5-HT2A and 5-HT1A antagonists also increase AAAD activity in striatum Mus musculus dopamine + CO2
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?

Synonyms

Synonyms Comment Organism
AAAD
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Mus musculus

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
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Mus musculus