Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-Dopa | Mus musculus | clozapine modulates AAAD activity in striatum and enhances exogenous L-DOPA decarboxylation in intact mice and mice lesioned with1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Kinetic analysis of AAAD at 1 h showed an increase in the apparent Vmax for both the substrate L-DOPA and the cofactor pyridoxal-5'-phosphate with no changes for Km. Dopamine D4 and 5-HT2A and 5-HT1A antagonists also increase AAAD activity in striatum | dopamine + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
male Swiss-Webster | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
corpus striatum | clozapine modulates AAAD activity in striatum and enhances exogenous L-DOPA decarboxylation in intact mice and mice lesioned with1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Kinetic analysis of AAAD at 1 h showed an increase in the apparent Vmax for both the substrate L-DOPA and the cofactor pyridoxal-5'-phosphate with no changes for Km. Dopamine D4 and 5-HT2A and 5-HT1A antagonists also increase AAAD activity in striatum | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3,4-Dihydroxyphenylalanine | i.e. L-dopa | Mus musculus | Dopamine + CO2 | - |
? | |
L-Dopa | clozapine modulates AAAD activity in striatum and enhances exogenous L-DOPA decarboxylation in intact mice and mice lesioned with1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Kinetic analysis of AAAD at 1 h showed an increase in the apparent Vmax for both the substrate L-DOPA and the cofactor pyridoxal-5'-phosphate with no changes for Km. Dopamine D4 and 5-HT2A and 5-HT1A antagonists also increase AAAD activity in striatum | Mus musculus | dopamine + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AAAD | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | - |
Mus musculus |