Literature summary for 4.1.1.28 extracted from

Doroudchi, M.M.; Liauw, J.; Heaton, K.; Zhen, Z.; Forsayeth, J.R.
Adeno-associated virus-mediated gene transfer of human aromatic L-amino acid decarboxylase protects mixed striatal primary cultures from L-DOPA toxicity (2005), J. Neurochem., 93, 634-640.

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Cloned(Commentary)

Cloned (Comment)	Organism
developed an adeno-associated virus vector that contains human AADC cDNA under the control of the cytomegalovirus promoter. Infusion of this vector into the striatum of parkinsonian rats and monkeys improves L-DOPA responsiveness by improving AADC-mediated conversion of L-DOPA to dopamine	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3,4-Dihydroxyphenylalanine	Homo sapiens	neuroprotective role for AADC against L-DOPA toxicity in primary striatal cultures. The protective effect is due primarily to AADC-dependent conversion of L-DOPA to dopamine, leading, in turn, to an increase in intracellular dopamine levels	Dopamine + CO2	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3,4-Dihydroxyphenylalanine	i.e. L-dopa	Homo sapiens	Dopamine + CO2	-	?
3,4-Dihydroxyphenylalanine	neuroprotective role for AADC against L-DOPA toxicity in primary striatal cultures. The protective effect is due primarily to AADC-dependent conversion of L-DOPA to dopamine, leading, in turn, to an increase in intracellular dopamine levels	Homo sapiens	Dopamine + CO2	-	?

Synonyms

Synonyms	Comment	Organism
AADC	-	Homo sapiens

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Release 2023.1 (January 2023)