Application | Comment | Organism |
---|---|---|
pharmacology | biosynthesis of pharmaceutically important monoterpenoid indole alkaloids | Drosophila melanogaster |
pharmacology | biosynthesis of pharmaceutically important monoterpenoid indole alkaloids | Sus scrofa |
pharmacology | biosynthesis of pharmaceutically important monoterpenoid indole alkaloids | Solanum lycopersicum |
pharmacology | biosynthesis of pharmaceutically important monoterpenoid indole alkaloids | Cinchona calisaya |
pharmacology | biosynthesis of pharmaceutically important monoterpenoid indole alkaloids | Catharanthus roseus |
pharmacology | biosynthesis of pharmaceutically important monoterpenoid indole alkaloids | Cinchona officinalis |
pharmacology | biosynthesis of pharmaceutically important monoterpenoid indole alkaloids | Camptotheca acuminata |
pharmacology | biosynthesis of pharmaceutically important monoterpenoid indole alkaloids | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
- |
Drosophila melanogaster |
- |
Sus scrofa |
- |
Solanum lycopersicum |
- |
Cinchona calisaya |
- |
Cinchona officinalis |
- |
Homo sapiens |
TDC encoded by a single-copy gene,TDC gene used to transform tobacco, Canola and potato plants and callus and root cultures from Peganum harmala | Catharanthus roseus |
two autonomously regulated genes, TDC1 and TDC2 | Camptotheca acuminata |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
D-tryptophan | non-competitive inhibitor | Catharanthus roseus | |
tryptamine | competitive inhibitor | Catharanthus roseus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
54000 | - |
2 * 54000 | Catharanthus roseus |
115000 | - |
- |
Catharanthus roseus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan | Sus scrofa | - |
tryptamine + CO2 | - |
? | |
L-tryptophan | Homo sapiens | - |
tryptamine + CO2 | - |
? | |
L-tryptophan | Solanum lycopersicum | implicated in the biosynthesis of the plant hormone indole-3-acetic acid, also involved in the formation of the monoamine serotonin, and of simple alkaloids such as the beta-carbolines | tryptamine + CO2 | - |
? | |
L-tryptophan | Cinchona calisaya | implicated in the biosynthesis of the plant hormone indole-3-acetic acid, also involved in the formation of the monoamine serotonin, and of simple alkaloids such as the beta-carbolines | tryptamine + CO2 | - |
? | |
L-tryptophan | Catharanthus roseus | implicated in the biosynthesis of the plant hormone indole-3-acetic acid, also involved in the formation of the monoamine serotonin, and of simple alkaloids such as the beta-carbolines | tryptamine + CO2 | - |
? | |
L-tryptophan | Cinchona officinalis | implicated in the biosynthesis of the plant hormone indole-3-acetic acid, also involved in the formation of the monoamine serotonin, and of simple alkaloids such as the beta-carbolines | tryptamine + CO2 | - |
? | |
L-tryptophan | Camptotheca acuminata | implicated in the biosynthesis of the plant hormone indole-3-acetic acid, also involved in the formation of the monoamine serotonin, and of simple alkaloids such as the beta-carbolines | tryptamine + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Camptotheca acuminata | P93082 | - |
- |
Catharanthus roseus | P17770 | - |
- |
Cinchona calisaya | - |
- |
- |
Cinchona officinalis | - |
- |
- |
Drosophila melanogaster | - |
fruit fly | - |
Homo sapiens | P20711 | human | - |
Solanum lycopersicum | - |
- |
- |
Sus scrofa | - |
pig | - |
Purification (Comment) | Organism |
---|---|
- |
Catharanthus roseus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-fluoro-L-tryptophan | - |
Catharanthus roseus | 4-fluorotryptamine + CO2 | - |
? | |
4-methyl-L-tryptophan | - |
Catharanthus roseus | 4-methyltryptamine + CO2 | - |
? | |
5-fluoro-L-tryptophan | - |
Catharanthus roseus | 5-fluorotryptamine + CO2 | - |
? | |
5-hydroxy-L-tryptophan | - |
Solanum lycopersicum | 5-hydroxytryptamine + CO2 | - |
? | |
5-hydroxy-L-tryptophan | - |
Cinchona calisaya | 5-hydroxytryptamine + CO2 | - |
? | |
5-hydroxy-L-tryptophan | - |
Catharanthus roseus | 5-hydroxytryptamine + CO2 | - |
? | |
5-hydroxy-L-tryptophan | - |
Camptotheca acuminata | 5-hydroxytryptamine + CO2 | - |
? | |
5-hydroxy-L-tryptophan | - |
Homo sapiens | 5-hydroxytryptamine + CO2 | - |
? | |
5-hydroxytryptophan | - |
Cinchona officinalis | 5-hydroxytryptamine + CO2 | - |
? | |
L-Dopa | - |
Drosophila melanogaster | dopamine + CO2 | - |
? | |
L-Dopa | - |
Sus scrofa | dopamine + CO2 | - |
? | |
L-Dopa | - |
Homo sapiens | dopamine + CO2 | - |
? | |
L-tryptophan | - |
Sus scrofa | tryptamine + CO2 | - |
? | |
L-tryptophan | - |
Solanum lycopersicum | tryptamine + CO2 | - |
? | |
L-tryptophan | - |
Cinchona calisaya | tryptamine + CO2 | - |
? | |
L-tryptophan | - |
Catharanthus roseus | tryptamine + CO2 | - |
? | |
L-tryptophan | - |
Cinchona officinalis | tryptamine + CO2 | - |
? | |
L-tryptophan | - |
Camptotheca acuminata | tryptamine + CO2 | - |
? | |
L-tryptophan | - |
Homo sapiens | tryptamine + CO2 | - |
? | |
L-tryptophan | implicated in the biosynthesis of the plant hormone indole-3-acetic acid, also involved in the formation of the monoamine serotonin, and of simple alkaloids such as the beta-carbolines | Solanum lycopersicum | tryptamine + CO2 | - |
? | |
L-tryptophan | implicated in the biosynthesis of the plant hormone indole-3-acetic acid, also involved in the formation of the monoamine serotonin, and of simple alkaloids such as the beta-carbolines | Cinchona calisaya | tryptamine + CO2 | - |
? | |
L-tryptophan | implicated in the biosynthesis of the plant hormone indole-3-acetic acid, also involved in the formation of the monoamine serotonin, and of simple alkaloids such as the beta-carbolines | Catharanthus roseus | tryptamine + CO2 | - |
? | |
L-tryptophan | implicated in the biosynthesis of the plant hormone indole-3-acetic acid, also involved in the formation of the monoamine serotonin, and of simple alkaloids such as the beta-carbolines | Cinchona officinalis | tryptamine + CO2 | - |
? | |
L-tryptophan | implicated in the biosynthesis of the plant hormone indole-3-acetic acid, also involved in the formation of the monoamine serotonin, and of simple alkaloids such as the beta-carbolines | Camptotheca acuminata | tryptamine + CO2 | - |
? | |
additional information | exclusive substrate specificity for L-amino acids with either indole or phenol side chains, but not both, L-tyrosine, L-phenylalanine and L-Dopa are not accepted as substrates | Solanum lycopersicum | ? | - |
? | |
additional information | exclusive substrate specificity for L-amino acids with either indole or phenol side chains, but not both, L-tyrosine, L-phenylalanine and L-Dopa are not accepted as substrates | Cinchona calisaya | ? | - |
? | |
additional information | exclusive substrate specificity for L-amino acids with either indole or phenol side chains, but not both, L-tyrosine, L-phenylalanine and L-Dopa are not accepted as substrates | Catharanthus roseus | ? | - |
? | |
additional information | exclusive substrate specificity for L-amino acids with either indole or phenol side chains, but not both, L-tyrosine, L-phenylalanine and L-Dopa are not accepted as substrates | Cinchona officinalis | ? | - |
? | |
additional information | exclusive substrate specificity for L-amino acids with either indole or phenol side chains, but not both, L-tyrosine, L-phenylalanine and L-Dopa are not accepted as substrates | Camptotheca acuminata | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 54000 | Catharanthus roseus |
Synonyms | Comment | Organism |
---|---|---|
AADC | - |
Drosophila melanogaster |
AADC | - |
Sus scrofa |
AADC | - |
Solanum lycopersicum |
AADC | - |
Cinchona calisaya |
AADC | - |
Catharanthus roseus |
AADC | - |
Cinchona officinalis |
AADC | - |
Camptotheca acuminata |
AADC | - |
Homo sapiens |
CrTDC | - |
Catharanthus roseus |
DDC | - |
Drosophila melanogaster |
DDC | - |
Sus scrofa |
DDC | - |
Homo sapiens |
EC 4.1.1.27 | formerly | Solanum lycopersicum |
EC 4.1.1.27 | formerly | Cinchona calisaya |
EC 4.1.1.27 | formerly | Catharanthus roseus |
EC 4.1.1.27 | formerly | Cinchona officinalis |
EC 4.1.1.27 | formerly | Camptotheca acuminata |
HsDDC | - |
Homo sapiens |
L-amino acid decarboxylase | - |
Drosophila melanogaster |
L-amino acid decarboxylase | - |
Sus scrofa |
L-amino acid decarboxylase | - |
Solanum lycopersicum |
L-amino acid decarboxylase | - |
Cinchona calisaya |
L-amino acid decarboxylase | - |
Catharanthus roseus |
L-amino acid decarboxylase | - |
Cinchona officinalis |
L-amino acid decarboxylase | - |
Camptotheca acuminata |
L-amino acid decarboxylase | - |
Homo sapiens |
L-DOPA decarboxylase | - |
Drosophila melanogaster |
L-DOPA decarboxylase | - |
Sus scrofa |
L-DOPA decarboxylase | - |
Homo sapiens |
L-Tryptophan decarboxylase | - |
Solanum lycopersicum |
L-Tryptophan decarboxylase | - |
Cinchona calisaya |
L-Tryptophan decarboxylase | - |
Catharanthus roseus |
L-Tryptophan decarboxylase | - |
Cinchona officinalis |
L-Tryptophan decarboxylase | - |
Camptotheca acuminata |
TDC | - |
Solanum lycopersicum |
TDC | - |
Cinchona calisaya |
TDC | - |
Catharanthus roseus |
TDC | - |
Cinchona officinalis |
TDC | - |
Camptotheca acuminata |
TDC2 | - |
Camptotheca acuminata |
tryptophan decarboxylase-1 | - |
Camptotheca acuminata |
tryptophan decarboxylase-2 | - |
Camptotheca acuminata |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | - |
Drosophila melanogaster | |
pyridoxal 5'-phosphate | - |
Sus scrofa | |
pyridoxal 5'-phosphate | - |
Solanum lycopersicum | |
pyridoxal 5'-phosphate | - |
Cinchona calisaya | |
pyridoxal 5'-phosphate | - |
Catharanthus roseus | |
pyridoxal 5'-phosphate | - |
Cinchona officinalis | |
pyridoxal 5'-phosphate | - |
Camptotheca acuminata | |
pyridoxal 5'-phosphate | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.31 | - |
tryptamine | - |
Catharanthus roseus |
Organism | Comment | pI Value Maximum | pI Value |
---|---|---|---|
Catharanthus roseus | - |
- |
5.9 |