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Literature summary for 4.1.1.23 extracted from

  • Tsang, W.Y.; Wood, B.M.; Wong, F.M.; Wu, W.; Gerlt, J.A.; Amyes, T.L.; Richard, J.P.
    Proton transfer from C-6 of uridine 5-monophosphate catalyzed by orotidine 5-monophosphate decarboxylase: formation and stability of a vinyl carbanion intermediate and the effect of a 5-fluoro substituent (2012), J. Am. Chem. Soc., 134, 14580-14594.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
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Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
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 Saccharomyces cerevisiae
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-Fluoroorotidine 5'-phosphate the 5-fluoro substituent results in a 3400fold increase in the first-order rate constant for deuterium exchange Saccharomyces cerevisiae 5-Fluorouridine 5'-phosphate + CO2
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additional information the total transition-state stabilization for decarboxylation of orotidine 5'-phosphate via the UMP vinyl carbanion intermediate exceeds that for the formation of this carbanion by proton transfer from C-6 of UMP to the enzyme by ca.17 kcal/mol. A large portion of the total transition-state stabilization for the decarboxylation of orotidine 5'-monophosphate can be accounted for by stabilization of the enzyme-bound vinyl carbanion intermediate of the stepwise reaction Saccharomyces cerevisiae ?
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Orotidine 5'-phosphate
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 Saccharomyces cerevisiae UMP + CO2
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