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Literature summary for 4.1.1.23 extracted from

  • Wong, F.M.; Capule, C.C.; Wu, W.
    Stability of the 6-carbanion of uracil analogues: mechanistic implications for model reactions of orotidine-5-monophosphate decarboxylase (2006), Org. Lett., 8, 6019-6022.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.1.1.23

Crystallization (Commentary)

Crystallization (Comment) Organism
PDB ID 1DQX, free enzyme and enzyme bound to 6-hydroxy-UMP, crystal structure analysis of the enzyme in presence or absence of a potenial transition state analogue, comparison to predicted structure by QM/MM enzyme simulations, overview Saccharomyces cerevisiae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information kinetics Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Orotidine 5'-phosphate Saccharomyces cerevisiae
-
 UMP + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Reaction

Reaction Comment Organism Reaction ID
orotidine 5'-phosphate = UMP + CO2 direct decarboxylation mechanism, modeling with 6-carbanion derivatives of uracil analogues, overview Saccharomyces cerevisiae
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Orotidine 5'-phosphate
-
 Saccharomyces cerevisiae UMP + CO2
-
 ?

Subunits

Subunits Comment Organism
More QM/MM enzyme simulations, free enzyme and enzyme bound to 6-hydroxy-UMP, QM/MM and metadynamics, enzyme structure analysis, overview Saccharomyces cerevisiae

Synonyms

Synonyms Comment Organism
orotidine-5-monophosphate decarboxylase
-
 Saccharomyces cerevisiae