Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-methylorotate | modeling of binding and structure | Methanothermobacter thermautotrophicus | |
6-amino-1-methyluracil | modeling of binding and structure | Methanothermobacter thermautotrophicus | |
6-amino-UMP | competitive inhibition | Methanothermobacter thermautotrophicus | |
6-aza-UMP | competitive inhibition | Methanothermobacter thermautotrophicus | |
6-cyano-1-methyluracil | modeling of binding and structure | Methanothermobacter thermautotrophicus | |
6-cyano-UMP | competitive inhibition | Methanothermobacter thermautotrophicus | |
6-hydroxy-1-methyl uracil | modeling of binding and structure | Methanothermobacter thermautotrophicus | |
barbituric acid monophosphate | i.e. 6-hydroxy-UMP | Methanothermobacter thermautotrophicus | |
additional information | inhibitor synthesis, overview | Methanothermobacter thermautotrophicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | kinetics | Methanothermobacter thermautotrophicus | |
0.005 | - |
orotidine 5'-phosphate | pH 7.5, 55°C | Methanothermobacter thermautotrophicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Orotidine 5'-phosphate | Methanothermobacter thermautotrophicus | - |
UMP + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Methanothermobacter thermautotrophicus | - |
- |
- |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Methanothermobacter thermautotrophicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme also converts 6-cyano-UMP to barbituric acid monophosphate with low activity | Methanothermobacter thermautotrophicus | ? | - |
? | |
Orotidine 5'-phosphate | - |
Methanothermobacter thermautotrophicus | UMP + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ODCase | - |
Methanothermobacter thermautotrophicus |
Orotidine monophosphate decarboxylase | - |
Methanothermobacter thermautotrophicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
55 | - |
assay at | Methanothermobacter thermautotrophicus |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
21 | - |
orotidine 5'-phosphate | pH 7.5, 55°C | Methanothermobacter thermautotrophicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Methanothermobacter thermautotrophicus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | inhibition kinetics, isothermal calorimetry | Methanothermobacter thermautotrophicus | |
0.00084 | - |
6-amino-UMP | pH 7.5, 55°C | Methanothermobacter thermautotrophicus | |
0.0124 | - |
6-aza-UMP | pH 7.5, 55°C | Methanothermobacter thermautotrophicus | |
0.029 | - |
6-cyano-UMP | pH 7.5, 55°C | Methanothermobacter thermautotrophicus |