Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Escherichia coli |
Crystallization (Comment) | Organism |
---|---|
uncomplexed apoenzyme and complexed with 1-(5-phospho-beta-D-ribofuranosyl)barbituric acid | Escherichia coli |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-(5'-phospho-beta-D-ribofuranosyl)barbituric acid | - |
Escherichia coli |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
additional information | no metals | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Orotidine 5'-phosphate | Escherichia coli | last step in the de novo synthesis of pyrimidine nucleotides | UMP + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Orotidine 5'-phosphate | enzyme/active site structure, contains two independently functioning active sites, binding of the phosphoryl group of the substrate is essential for the catalytic function, induced fit mechanism | Escherichia coli | UMP + CO2 | - |
? | |
Orotidine 5'-phosphate | last step in the de novo synthesis of pyrimidine nucleotides | Escherichia coli | UMP + CO2 | - |
? |
Subunits | Comment | Organism |
---|---|---|
homodimer | - |
Escherichia coli |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
additional information | no cofactors | Escherichia coli |