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Literature summary for 4.1.1.22 extracted from

  • Tsolakis, A.V.; Grimelius, L.; Granerus, G.; Stridsberg, M.; Falkmer, S.E.; Janson, E.T.
    Histidine decarboxylase and urinary methylimidazoleacetic acid in gastric neuroendocrine cells and tumours (2015), World J. Gastroenterol., 21, 13240-13249 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.1.1.22

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-histidine Homo sapiens
-
 histamine + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P19113
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fundic mucosa
-
 Homo sapiens
-
gastric adenocarcinoma cell
-
 Homo sapiens
-
gastric mucosa the tumours are classified based on clinico-pathological criteria Homo sapiens
-
additional information histidine decarboxylase (HDC) expression in healthy and neoplastic gastric neuroendocrine cells in relationship to the main histamine metabolite, immunoreactive localization study, overview Homo sapiens
-
neuroendocrine tumor cell human oxyntic mucosa contains four major types of neuroendocrine cells: ECL, ghrelin, serotonin and somatostatin cells Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-histidine
-
 Homo sapiens histamine + CO2
-
 ?

Synonyms

Synonyms Comment Organism
HDC
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function human oxyntic mucosa contains four major types of neuroendocrine cells (ECL, ghrelin, serotonin and somatostatin cells). ECL cells are the most abundant type, and they produce histamine. The histamine-synthesizing ability of ECL cells is based on cytosolic HDC. Histamine might be transported by VMAT-2 into the secretory vesicles Homo sapiens