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Literature summary for 4.1.1.22 extracted from

  • Hoffman, G.E.; Koban, M.
    Hypothalamic L-histidine decarboxylase is up-regulated during chronic REM sleep deprivation of rats (2016), PLoS ONE, 11, e0152252 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-histidine Rattus norvegicus
-
 histamine + CO2
-
 ?
L-histidine Rattus norvegicus Sprague-Dawley
-
 histamine + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P16453
-
-
Rattus norvegicus Sprague-Dawley P16453
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-
hypothalamus
-
 Rattus norvegicus
-
additional information immunolocalization of histamine, with rabbit anti-L-histidine decarboxylase (HDC) antiserum, within the tuberomammillary nucleus is validated using carbodiimide. Rapid eye movement sleep deprivation (REM-SD) increases immunoreactive L-histidine decarboxylase by day 5, and it remains elevated in both dorsal and ventral aspects of the tuberomammillary complex Rattus norvegicus
-
neuron neurons of the tuberomammillary nucleus of the posterior hypothalamus Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-histidine
-
 Rattus norvegicus histamine + CO2
-
 ?
L-histidine
-
 Rattus norvegicus Sprague-Dawley histamine + CO2
-
 ?

Synonyms

Synonyms Comment Organism
HDC
-
 Rattus norvegicus
L-Histidine decarboxylase
-
 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus rapid eye movement sleep deprivation (REM-SD) increases immunoreactive L-histidine decarboxylase by day 5, and it remains elevated in both dorsal and ventral aspects of the tuberomammillary complex up

General Information

General Information Comment Organism
metabolism L-histidine decarboxylase is the rate-limiting enzyme for histamine biosynthesis Rattus norvegicus
physiological function L-histidine decarboxylase (HDC) is the enzyme responsible for histamine biosynthesis in tuberomammillary nucleus (TMN) neurons of the posterior hypothalamus, the rate-limiting enzyme for histamine biosynthesis might be upregulated during chronic rapid eye movement sleep deprivation (REM-SD) because histamine plays a major role in maintaining wakefulness. Upregulation of L-HDC within the tuberomammillary complex during chronic REM-SD is responsible for maintaining wakefulness. Chronic loss of sleep causes the rat to manifest a number of pathologies or syndromes Rattus norvegicus