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Literature summary for 4.1.1.22 extracted from
- Histidine decarboxylase from rat and rabbit brain: partial purification and characterization (1990), Neurochem. Res., 15, 17-24.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| alpha-Fluoromethylhistidine | - |
Oryctolagus cuniculus |  |
| alpha-Fluoromethylhistidine | - |
Rattus norvegicus | |
| CoCl2 | - |
Oryctolagus cuniculus | |
| CoCl2 | - |
Rattus norvegicus | |
| NiCl2 | - |
Oryctolagus cuniculus | |
| NiCl2 | - |
Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.078 | - |
L-His | - |
Rattus norvegicus | |
| 0.12 | - |
L-His | - |
Oryctolagus cuniculus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Oryctolagus cuniculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Rattus norvegicus |
| partial | Oryctolagus cuniculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Rattus norvegicus | - |
| brain | - |
Oryctolagus cuniculus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Rattus norvegicus |
| additional information | - |
- |
Oryctolagus cuniculus |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -70°C, 94% of the original activity in the fresh preparation | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-His | - |
Rattus norvegicus | Histamine + CO2 | - |
? | |
| L-His | - |
Oryctolagus cuniculus | Histamine + CO2 | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 45 | - |
- |
Rattus norvegicus |
| 45 | - |
- |
Oryctolagus cuniculus |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 55 | - |
denaturation of enzyme activity | Rattus norvegicus |
| 55 | - |
denaturation of enzyme activity | Oryctolagus cuniculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.2 | 8 | - |
Rattus norvegicus |
| 7.2 | 8 | - |
Oryctolagus cuniculus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 7 | 9 | pH 7.0: about 85% of maximal activity, pH 9.0: about 70% of maximal activity | Oryctolagus cuniculus |
| 7 | 9 | about 45% of maximal activity at pH 7.0 and at pH 9.0 | Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | required | Rattus norvegicus | |
| pyridoxal 5'-phosphate | required | Oryctolagus cuniculus | |
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