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Literature summary for 4.1.1.22 extracted from
- Purification and properties of a pyridoxal 5'-phosphate-dependent histidine decarboxylase from Morganella morganii AM-15 (1985), J. Biol. Chem., 260, 6738-6746.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-Hydrazino-3-(4-imidazolyl)propionic acid | - |
Morganella morganii |  |
| alpha-Fluoromethylhistidine | irreversible | Morganella morganii | |
| alpha-Methylhistidine | - |
Morganella morganii | |
| dithiothreitol | - |
Morganella morganii | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1.2 | - |
L-His | pH 6.5-6.7 | Morganella morganii | |
| 5.8 | - |
1-methyl-DL-histidine | - |
Morganella morganii |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 43000 | - |
4 * 43000, SDS-PAGE | Morganella morganii |
| 113400 | - |
gel filtration | Morganella morganii |
| 170000 | - |
gel filtration | Morganella morganii |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Morganella morganii | - |
- |
- |
| Morganella morganii AM-15 | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Morganella morganii |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-methyl-DL-histidine | - |
Morganella morganii | 1-methylhistamine + CO2 | - |
? | |
| 1-methyl-DL-histidine | - |
Morganella morganii AM-15 | 1-methylhistamine + CO2 | - |
? | |
| beta-(Pyridyl-2)-Ala | - |
Morganella morganii | ? | - |
? | |
| beta-(Pyridyl-2)-Ala | - |
Morganella morganii AM-15 | ? | - |
? | |
| L-His | - |
Morganella morganii | Histamine + CO2 | - |
? | |
| L-His | - |
Morganella morganii AM-15 | Histamine + CO2 | - |
? | |
| Npi-Methylhistidine | - |
Morganella morganii | ? | - |
? | |
| Npi-Methylhistidine | - |
Morganella morganii AM-15 | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| tetramer | 4 * 43000, SDS-PAGE | Morganella morganii |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 40 | - |
not stable beyond 40°C | Morganella morganii |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | - |
- |
Morganella morganii |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | the enzyme binds 4 pyridoxal 5'-phosphate per tetramer | Morganella morganii | |
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