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Literature summary for 4.1.1.22 extracted from

  • Tran, V.T.; Snyder, S.H.
    Histidine decarboxylase. Purification from fetal rat liver, immunologic properties, and histochemical localization in brain and stomach (1981), J. Biol. Chem., 256, 680-686.
    View publication on PubMed
Search for more literature for 4.1.1.22

General Stability

General Stability Organism
after dialysis for 48 h against buffer containing 1 mM semicarbazide, about 50% loss of activity, full recovery by adding pyridoxal 5'-phosphate Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
5,5'-dithiobis(2-nitrobenzoate)
-
 Rattus norvegicus
alpha-Fluoromethylhistidine the (S)-isomer is a suicide substrate inhibitor, the (R)-isomer is an at least 10times less potent inhibitor Rattus norvegicus
Co(NO3)2 slight Rattus norvegicus
HgCl2
-
 Rattus norvegicus
ZnCl2
-
 Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information between pH 6 and pH 9 the Km-value for L-His declines from 1 mM to about 0.01 mM Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
66000
-
 1 * 145000, alpha, + 1 * 66000, beta, SDS-PAGE Rattus norvegicus
145000
-
 1 * 145000, alpha, + 1 * 66000, beta, SDS-PAGE Rattus norvegicus
210000
-
 gel filtration Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-
gastric mucosa
-
 Rattus norvegicus
-
liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Rattus norvegicus

Storage Stability

Storage Stability Organism
-70°C, no loss of activity for at least 6 months Rattus norvegicus
4°C, stable for about 1 week Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-His
-
 Rattus norvegicus Histamine + CO2
-
 ?

Subunits

Subunits Comment Organism
dimer 1 * 145000, alpha, + 1 * 66000, beta, SDS-PAGE Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.8
-
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate after dialysis for 48 h against buffer containing 1 mM semicarbazide, about 50% loss of activity, full recovery by adding pyridoxal 5'-phosphate. Km: 0.001 mM Rattus norvegicus