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Literature summary for 4.1.1.19 extracted from

  • Hong, S.; Son, M.R.; Yun, K.; Lee, W.T.; Park, K.A.; Lee, J.E.
    Retroviral expression of human arginine decarboxylase reduces oxidative stress injury in mouse cortical astrocytes (2014), BMC Neurosci., 15, 99 .
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
gene ADC, functional overexpression from retroviral vector hADC pLXSN in murine cortical astrocytes leading to and astrocyte-protective effect of human arginine decarboxylase transduction against oxygen-glucose deprivation (OGD), overview Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information agmatine-producing mouse cortical astrocytes were developed through transduction of the transformed heterologous human ADC gene Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-arginine Homo sapiens
-
 agmatine + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
central nervous system
-
 Homo sapiens
-
glial cell
-
 Homo sapiens
-
neuron
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-arginine
-
 Homo sapiens agmatine + CO2
-
 ?

Synonyms

Synonyms Comment Organism
ADC
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function agmatine, an endogenous polyamine catalyzed from L-arginine by arginine decarboxylase (ADC), is a neuromodulator that protects neurons/glia against various injuries. Agmatine, is naturally found in the mammalian central nervous system (CNS) and acts as a multifunctional neuromodulator. It is packed into synaptic vesicles and released from synaptosomes by neuronal depolarization. Agmatine can stimulate alpha2-adrenergic and imidazoline receptors. Retroviral expression of human arginine decarboxylase reduces oxidative stress injury in mouse cortical astrocytes Homo sapiens