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Literature summary for 4.1.1.18 extracted from

  • Kim, H.J.; Kim, Y.H.; Shin, J.H.; Bhatia, S.K.; Sathiyanarayanan, G.; Seo, H.M.; Choi, K.Y.; Yang, Y.H.; Park, K.
    Optimization of direct lysine decarboxylase biotransformation for cadaverine production with whole-cell biocatalysts at high lysine concentration (2015), J. Microbiol. Biotechnol., 25, 1108-1113 .
    View publication on PubMed
Search for more literature for 4.1.1.18

Protein Variants

Protein Variants Comment Organism
additional information optimization of direct lysine decarboxylase biotransformation of lysine to cadaverine for cadaverine production with whole-cell biocatalysts at high lysine concentration. Consumption of 91% lysine and conversion of about 80% lysine to cadaverine at 0.025 mM pyridoxal 5'-phosphate and 1.75 M lysine in 500 mM sodium acetate buffer, pH 6.0 Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
L-lysine substrate inhibition is observed from 1.25 M Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-lysine Escherichia coli
-
 cadaverine + CO2
-
 ?
L-lysine Escherichia coli K-12 / MG1655
-
 cadaverine + CO2
-
 ?
additional information Escherichia coli optimization of direct lysine decarboxylase biotransformation of lysine to cadaverine for cadaverine production with whole-cell biocatalysts at high lysine concentration. Consumption of 91% lysine and conversion of about 80% lysine to cadaverine at 0.025 mM pyridoxal 5'-phosphate and 1.75 M lysine in 500 mM sodium acetate buffer, pH 6.0 ?
-
 ?
additional information Escherichia coli K-12 / MG1655 optimization of direct lysine decarboxylase biotransformation of lysine to cadaverine for cadaverine production with whole-cell biocatalysts at high lysine concentration. Consumption of 91% lysine and conversion of about 80% lysine to cadaverine at 0.025 mM pyridoxal 5'-phosphate and 1.75 M lysine in 500 mM sodium acetate buffer, pH 6.0 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli P0A9H3
-
-
Escherichia coli K-12 / MG1655 P0A9H3
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-lysine
-
 Escherichia coli cadaverine + CO2
-
 ?
L-lysine
-
 Escherichia coli K-12 / MG1655 cadaverine + CO2
-
 ?
additional information optimization of direct lysine decarboxylase biotransformation of lysine to cadaverine for cadaverine production with whole-cell biocatalysts at high lysine concentration. Consumption of 91% lysine and conversion of about 80% lysine to cadaverine at 0.025 mM pyridoxal 5'-phosphate and 1.75 M lysine in 500 mM sodium acetate buffer, pH 6.0 Escherichia coli ?
-
 ?
additional information optimization of direct lysine decarboxylase biotransformation of lysine to cadaverine for cadaverine production with whole-cell biocatalysts at high lysine concentration. Consumption of 91% lysine and conversion of about 80% lysine to cadaverine at 0.025 mM pyridoxal 5'-phosphate and 1.75 M lysine in 500 mM sodium acetate buffer, pH 6.0 Escherichia coli K-12 / MG1655 ?
-
 ?

Synonyms

Synonyms Comment Organism
CadA
-
 Escherichia coli

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Escherichia coli

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6
-
 assay at Escherichia coli

pH Range

pH Minimum pH Maximum Comment Organism
additional information
-
 the cadaverine conversion rate is negatively affected at above pH 9 Escherichia coli

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate dependent on, best at 0.025-0.1 mM in whole-cell assay Escherichia coli