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Literature summary for 4.1.1.18 extracted from

  • Li, N.; Yu, L.; Xu, Y.
    Heterologous expression and characterization of Klebsiella oxytoca lysine decarboxylase (2016), Chin. J. Biotechnol., 32, 527-531 .
    View publication on PubMed

Application

Application Comment Organism
synthesis the enzyme can be used for synthesis of cadaverine, a biogenic amine, that has the potential to become an important platform chemical for the production of industrial polymers, such as polyamides and polyurethanes Klebsiella oxytoca

Cloned(Commentary)

Cloned (Comment) Organism
gene lysA, recombinant enzyme overexpression in Escherichia coli strain LN18 Klebsiella oxytoca

Inhibitors

Inhibitors Comment Organism Structure
Ca2+
-
Klebsiella oxytoca
Fe2+
-
Klebsiella oxytoca
Zn2+
-
Klebsiella oxytoca

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ activates Klebsiella oxytoca

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-lysine Klebsiella oxytoca
-
cadaverine + CO2
-
?
L-lysine Klebsiella oxytoca ATCC 8724 / DSM 4798 / JCM 20051 / NBRC 3318 / NRRL B-199 / KCTC 1686
-
cadaverine + CO2
-
?

Organism

Organism UniProt Comment Textmining
Klebsiella oxytoca A0A0H3H393
-
-
Klebsiella oxytoca ATCC 8724 / DSM 4798 / JCM 20051 / NBRC 3318 / NRRL B-199 / KCTC 1686 A0A0H3H393
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-lysine
-
Klebsiella oxytoca cadaverine + CO2
-
?
L-lysine
-
Klebsiella oxytoca ATCC 8724 / DSM 4798 / JCM 20051 / NBRC 3318 / NRRL B-199 / KCTC 1686 cadaverine + CO2
-
?

Subunits

Subunits Comment Organism
? x * 80000, recombinant enzyme Klebsiella oxytoca

Synonyms

Synonyms Comment Organism
LysA
-
Klebsiella oxytoca

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
55
-
recombinant enzyme Klebsiella oxytoca

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.5
-
recombinant enzyme Klebsiella oxytoca

pH Range

pH Minimum pH Maximum Comment Organism
5.5 8 maximal activity at pH 5.5, 30% of maximal activity at pH 8.0 Klebsiella oxytoca

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
Klebsiella oxytoca