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Literature summary for 4.1.1.18 extracted from

  • Li, N.; Chou, H.; Yu, L.; Xu, Y.
    Cadaverine production by heterologous expression of Klebsiella oxytoca lysine decarboxylase (2014), Biotechnol. Bioprocess Eng., 19, 965-972 .
No PubMed abstract available
Search for more literature for 4.1.1.18

Application

Application Comment Organism
synthesis the enzyme can be used for synthesis of cadaverine, a biogenic amine, that has the potential to become an important platform chemical for the production of industrial polymers, such as polyamides, polyurethanes, and nylon. Nylon is one of the most commonly used polymers, and cadaverine has the potential to substitute hexamethylenediamine to produce nylon-5,4, nylon-5,6, nylon-5,10, or nylon-5,12 Klebsiella oxytoca

Cloned(Commentary)

Cloned (Comment) Organism
gene ldc, recombinant expression of wild-type enzyme and codon-optimized enzyme in Escherichia coli K-12 resulting in strains LN18 and LN20, respectively. Batch and fed-batch production of Klebsiella oxytoca lysine decarboxylase from several modifed strains, overview Klebsiella oxytoca

Protein Variants

Protein Variants Comment Organism
additional information biotransformation of cadaverine using a lysine decarboxylase from Klebsiella oxytoca expressed in Escherichia coli. Codon optimization of the gene encoding the enzyme is carried on for the heterologous expression in Escherichia coli, which leads to a system that converts more than 24% lysine-HCl to cadaverine compared to the same system expressing CadA, overview. The final optimized system converts lysine-HCl to cadaverine at a conversion rate of 0.133%/min/g Klebsiella oxytoca

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-lysine Klebsiella oxytoca
-
 cadaverine + CO2
-
 ?
L-lysine Klebsiella oxytoca DSM 6673
-
 cadaverine + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Klebsiella oxytoca
-
-
-
Klebsiella oxytoca DSM 6673
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-lysine
-
 Klebsiella oxytoca cadaverine + CO2
-
 ?
L-lysine
-
 Klebsiella oxytoca DSM 6673 cadaverine + CO2
-
 ?

Synonyms

Synonyms Comment Organism
LDC
-
 Klebsiella oxytoca

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Klebsiella oxytoca