Literature summary for 4.1.1.18 extracted from

Burrell, M.; Hanfrey, C.C.; Kinch, L.N.; Elliott, K.A.; Michael, A.J.
Evolution of a novel lysine decarboxylase in siderophore biosynthesis (2012), Mol. Microbiol., 86, 485-499.

Search for more literature for 4.1.1.18

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.058	-	L-lysine	pH 7.5, 30°C	Streptomyces coelicolor
1.3	-	L-2,4-diaminobutanoate	pH 7.5, 30°C	Streptomyces coelicolor

Organism

Organism	UniProt	Comment	Textmining
Streptomyces coelicolor	Q9L072	-	-
Streptomyces coelicolor ATCC BAA-471	Q9L072	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-2,4-diaminobutanoate	-	Streptomyces coelicolor	1,3-diaminopropane + CO2	-	?
L-2,4-diaminobutanoate	-	Streptomyces coelicolor ATCC BAA-471	1,3-diaminopropane + CO2	-	?
L-lysine	best substrate	Streptomyces coelicolor	1,5-diaminopentane + CO2	-	?
L-lysine	best substrate	Streptomyces coelicolor ATCC BAA-471	1,5-diaminopentane + CO2	-	?
L-ornithine	-	Streptomyces coelicolor	1,4-diaminobutane + CO2	-	?
L-ornithine	-	Streptomyces coelicolor ATCC BAA-471	1,4-diaminobutane + CO2	-	?

Synonyms

Synonyms	Comment	Organism
DesA	-	Streptomyces coelicolor

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
0.052	-	L-2,4-diaminobutanoate	pH 7.5, 30°C	Streptomyces coelicolor

General Information

General Information	Comment	Organism
physiological function	enzyme is involved in NRPS-independent siderophore biosynthesis	Streptomyces coelicolor

kcat/KM [mM/s]

kcat/KM Value [1/mMs^-1]	kcat/KM Value Maximum [1/mMs^-1]	Substrate	Comment	Organism	Structure
40	-	L-2,4-diaminobutanoate	pH 7.5, 30°C	Streptomyces coelicolor
690	-	L-lysine	pH 7.5, 30°C	Streptomyces coelicolor

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Release 2023.1 (January 2023)