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Literature summary for 4.1.1.17 extracted from
- Cloning, expression and characterization of the ornithine decarboxylase gene from Dictyostelium discoideum (2014), Int. J. Dev. Biol., 58, 669-676 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene odc, located on chromosome 3 between coxadordinates 4069177 to 4070741, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic tree, domain organization, recombinant expression of a fluorescence-tagged enzyme in Dictyostelium discoideum cells | Dictyostelium discoideum |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | enzyme overexpression in Dictyostelium discoideum cells inhibits cell proliferation and leads to mild developmental defect, because high putrescine levels are detrimental for cell proliferation, phenotype, overview | Dictyostelium discoideum |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Dictyostelium discoideum | 5829 | - |
| additional information | the enzyme is predominantly perinuclear but also cytosolic, subcellular localization analysis | Dictyostelium discoideum | - |
- |
| perinuclear space | - |
Dictyostelium discoideum | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-ornithine | Dictyostelium discoideum | - |
putrescine + CO2 | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Dictyostelium discoideum | Q54UF3 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| additional information | both ODC transcript and protein are expressed at all stages of development and show high expression in prestalk/stalk cells | Dictyostelium discoideum | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-ornithine | - |
Dictyostelium discoideum | putrescine + CO2 | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 51700, about, sequence calculation | Dictyostelium discoideum |
| More | tertiary structure prediction of putative Dictyostelium discoideum ornithine decarboxylase (DdODC), overview | Dictyostelium discoideum |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DDB_G0281109 | locus name | Dictyostelium discoideum |
| DdODC | - |
Dictyostelium discoideum |
| ODC | - |
Dictyostelium discoideum |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | - |
Dictyostelium discoideum | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | both overexpression of DdODC and putrescine treatment result in inhibition of cell proliferation | Dictyostelium discoideum |
| additional information | ODC secondary and tertiary structure homology modeling | Dictyostelium discoideum |
| physiological function | ornithine decarboxylase (ODC) is a rate limiting enzyme in polyamine synthesis that decarboxylates ornithine to form the diamine putrescine. The enzyme is predominantly expressed in the prestalk/stalk cells of multicellular structures | Dictyostelium discoideum |
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