Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Rattus norvegicus | 5737 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-ornithine | Rattus norvegicus | - |
putrescine + CO2 | - |
? | |
L-ornithine | Rattus norvegicus Wistar | - |
putrescine + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | P09057 | - |
- |
Rattus norvegicus Wistar | P09057 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
gastric cancer cell | relationship between expression level of the enzyme and mucosal proliferation, overview | Rattus norvegicus | - |
gastric mucosa | analysis of expression of the cancer-related protein ornithine decarboxylase (ODC) in nontransformed gastric mucosa, relationship between expression level of the enzyme and mucosal proliferation, overview | Rattus norvegicus | - |
additional information | immunohistochemic expression analysis of gene ODC, the ODC protein is detected mainly in the cytoplasm of the epithelial cells in all 3 groups of animals, i.e. unoperated rats, operated rats fed a normal diet, and operated rats given a carbonate-supplemented diet, also some stromal and inflammatory cells are positively stained, overview | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-ornithine | - |
Rattus norvegicus | putrescine + CO2 | - |
? | |
L-ornithine | - |
Rattus norvegicus Wistar | putrescine + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ODC | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Rattus norvegicus | carbonate ions lead to increased expression of ODC with cancer-inducing effect | up |
General Information | Comment | Organism |
---|---|---|
physiological function | Ornithine decarboxylase (ODC) is the key enzyme in polyamine synthesis and a regulator of cell proliferation. ODC enhances cell proliferation in the gastric mucosa | Rattus norvegicus |