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Literature summary for 4.1.1.17 extracted from

  • Chen, Y.; Weeks, R.S.; Burns, M.R.; Boorman, D.W.; Klein-Szanto, A.; O'Brien, T.G.
    Combination therapy with 2-difluoromethylornithine and a polyamine transport inhibitor against murine squamous cell carcinoma (2006), Int. J. Cancer, 118, 2344-2349 .
No PubMed abstract available

Application

Application Comment Organism
medicine targeting both polyamine biosynthesis via ODC through 2-difluoromethylornithine and polyamine transport through MQT 1426 from the tumor microenvironment enhances the efficacy of polyamine-based therapy in this mouse model of squamous cell carcinoma, overview Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
2-difluoromethylornithine DFMO, is used in therapy combined with MQT 1426, a polyamine transport inhibitor, for treatment of squamous cell carcinoma in a mouse model, K6/ODC Mus musculus
additional information MQT 1426 has no inhibitory effect on squamous cell carcinoma ODC activity nor does it enhance the inhibition by 2-difluoromethylornithine, but it reduces the polyamine levels in squamous cell carcinoma cells Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-ornithine Mus musculus
-
putrescine + CO2
-
?
L-ornithine Mus musculus C57BL/6J
-
putrescine + CO2
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus P00860
-
-
Mus musculus C57BL/6J P00860
-
-

Source Tissue

Source Tissue Comment Organism Textmining
squamous cell carcinoma cell
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-ornithine
-
Mus musculus putrescine + CO2
-
?
L-ornithine
-
Mus musculus C57BL/6J putrescine + CO2
-
?

Synonyms

Synonyms Comment Organism
ODC
-
Mus musculus

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
Mus musculus

General Information

General Information Comment Organism
physiological function enzyme ODC is involved in polyamine biosynthesis and squamous cell carcinoma proliferation Mus musculus