Literature summary for 4.1.1.17 extracted from

Snapir, Z.; Keren-Paz, A.; Bercovich, Z.; Kahana, C.
ODCp, a brain- and testis-specific ornithine decarboxylase paralogue, functions as an antizyme inhibitor, although less efficiently than AzI1 (2008), Biochem. J., 410, 613-619 .

Search for more literature for 4.1.1.17

Activating Compound

Activating Compound	Comment	Organism	Structure
antizyme inhibitor AzI1	AzI1 stimulates ODC activity, polyamine uptake and growth rate of enzyme ODC. AzI saves ODC from Az-induced degradation and it increases polyamine uptake. Superiority of AzI1 to ODCp in inhibiting the Az-stimulated ODC degradation. AzI, likeODCp, is degraded in a ubiquitin-dependent manner, in a reaction that does not require either interaction with Az or the integrity of its C-terminus	Homo sapiens
ODCp	ODC-related protein or ODC paralogue, another ODCp is suggested to function as antizyme, like AzI, showing ability to increase ODC activity and inhibit Az-stimulated ODC degradation in vitro. ODCp is indeed capable of negating Az functions, as reflected by its ability to increase ODC activity and polyamine uptake and by its ability to provide growth advantage in stably transfected cells. But ODCp is less potent than AzI1 in stimulating ODC activity, polyamine uptake, and growth rate. ODCp, like AzI, is degraded in a ubiquitin-dependent manner, in a reaction that does not require either interaction with Az or the integrity of its C-terminus. Its degradation is inhibited by inactivation of a thermosensitive ubiquitin-activating enzyme, E1. And Az inhibits ODCp degradation by interfering with its ubiquitination. Interaction with Az actually stabilizes ODCp by interfering with its ubiquitination. An ODCp chimaera containing the C-terminal degradation signal of ODC is still stabilized by Az. Superiority of AzI1 to ODCp in inhibiting the Az-stimulated ODC degradation because ODCp shows lower affinity towards Az (Az1 and Az3). Human ODCp is stably overexpressed in NIH 3T3-derived cells and in HEK-293 cells, either alone or together with Az1	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	ODC paralogue ODCp-overexpressing cells display elevated ODC and polyamine uptake activity as compared with control cells	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P11926	-	-

Synonyms

Synonyms	Comment	Organism
ODC	-	Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Homo sapiens

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.5	-	assay at	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
pyridoxal 5'-phosphate	-	Homo sapiens

General Information

General Information	Comment	Organism
metabolism	ornithine decarboxylase (ODC) degradation is stimulated by Az (antizyme), a polyamine-induced protein, which in turn is regulated by an ODC-related protein termed AzI (Az inhibitor)	Homo sapiens
physiological function	ornithine decarboxylase (ODC) is the first enzyme in the polyamine biosynthesis pathway in mammalian cells	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)