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Literature summary for 4.1.1.17 extracted from

  • Lange, I.; Geerts, D.; Feith, D.J.; Mocz, G.; Koster, J.; Bachmann, A.S.
    Novel interaction of ornithine decarboxylase with sepiapterin reductase regulates neuroblastoma cell proliferation (2014), J. Mol. Biol., 426, 332-346.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine ornithine decarboxylase and sepiapterin reductase physically interact. In a cohort of 88 human neuroblastoma tumors, high sepiapterin reductase mRNA expression correlates significantly with poor survival prognosis, suggesting an oncogenic role for sepiapterin reductase in neuroblastoma tumorigenesis Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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General Information

General Information Comment Organism
physiological function ornithine decarboxylase and sepiapterin reductase physically interact. The resulting heterocomplex is a compact structure, featuring two energetically and structurally equivalent binding modes both in monomer and in dimer conformations. siRNA-mediated knockdown of sepiapterin reductase expression significantly reduces endogenous ornithine decarboxylase enzyme activity in neuroblastoma cells Homo sapiens