Literature summary for 4.1.1.17 extracted from

Romano, A.; Trip, H.; Lonvaud-Funel, A.; Lolkema, J.S.; Lucas, P.M.
Evidence of two functionally distinct ornithine decarboxylation systems in lactic acid bacteria (2012), Appl. Environ. Microbiol., 78, 1953-1961.

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism
0.7	-	L-ornithine	30°C, pH 5.5	Oenococcus oeni
1	-	L-ornithine	30°C, pH 5.5	Levilactobacillus brevis
1	2.1	L-2,4-diaminobutanoate	30°C, pH 7.5	Lactobacillus gasseri
1	1.2	L-2,4-diaminobutanoate	30°C, pH 5.5	Levilactobacillus brevis
3.9	-	L-2,4-diaminobutanoate	30°C, pH 7.5	Lacticaseibacillus casei
4.9	-	L-2,4-diaminobutanoate	30°C, pH 5.5	Oenococcus oeni
5	-	L-lysine	30°C, pH 5.5	Oenococcus oeni
7.2	-	L-ornithine	30°C, pH 7.5	Lactobacillus gasseri
7.2	-	L-lysine	30°C, pH 5.5	Levilactobacillus brevis

Organism

Organism	UniProt	Comment	Textmining
Lacticaseibacillus casei	Q038E5	-	-
Lacticaseibacillus casei ATCC 334	Q038E5	-	-
Lactobacillus gasseri	A0A1V3Y1D0	-	-
Lactobacillus gasseri DSM 20243	A0A1V3Y1D0	-	-
Levilactobacillus brevis	H8ZI01	-	-
Oenococcus oeni	Q5ZH57	-	-
Oenococcus oeni IOEB 89006	Q5ZH57	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.
L-2,4-diaminobutanoate	-	Oenococcus oeni	1,3-diaminopropane + CO2	-	?
L-2,4-diaminobutanoate	-	Levilactobacillus brevis	1,3-diaminopropane + CO2	-	?
L-2,4-diaminobutanoate	-	Lacticaseibacillus casei	1,3-diaminopropane + CO2	-	?
L-2,4-diaminobutanoate	-	Lactobacillus gasseri	1,3-diaminopropane + CO2	-	?
L-2,4-diaminobutanoate	-	Lacticaseibacillus casei ATCC 334	1,3-diaminopropane + CO2	-	?
L-2,4-diaminobutanoate	-	Lactobacillus gasseri DSM 20243	1,3-diaminopropane + CO2	-	?
L-2,4-diaminobutanoate	-	Oenococcus oeni IOEB 89006	1,3-diaminopropane + CO2	-	?
L-lysine	-	Oenococcus oeni	1,5-diaminopentane + CO2	-	?
L-lysine	-	Levilactobacillus brevis	1,5-diaminopentane + CO2	-	?
L-lysine	very low activity	Lacticaseibacillus casei	1,5-diaminopentane + CO2	-	?
L-lysine	very low activity	Lactobacillus gasseri	1,5-diaminopentane + CO2	-	?
L-lysine	very low activity	Lacticaseibacillus casei ATCC 334	1,5-diaminopentane + CO2	-	?
L-lysine	very low activity	Lactobacillus gasseri DSM 20243	1,5-diaminopentane + CO2	-	?
L-lysine	-	Oenococcus oeni IOEB 89006	1,5-diaminopentane + CO2	-	?
L-ornithine	-	Oenococcus oeni	putrescine + CO2	-	?
L-ornithine	-	Levilactobacillus brevis	putrescine + CO2	-	?
L-ornithine	-	Lactobacillus gasseri	putrescine + CO2	-	?
L-ornithine	very low activity	Lacticaseibacillus casei	putrescine + CO2	-	?
L-ornithine	very low activity	Lacticaseibacillus casei ATCC 334	putrescine + CO2	-	?
L-ornithine	-	Lactobacillus gasseri DSM 20243	putrescine + CO2	-	?
L-ornithine	-	Oenococcus oeni IOEB 89006	putrescine + CO2	-	?
additional information	no substrate: L-arginine	Oenococcus oeni	?	-	?
additional information	no substrate: L-arginine	Levilactobacillus brevis	?	-	?
additional information	no substrate: L-arginine	Lacticaseibacillus casei	?	-	?
additional information	no substrate: L-arginine	Lactobacillus gasseri	?	-	?
additional information	no substrate: L-arginine	Lacticaseibacillus casei ATCC 334	?	-	?
additional information	no substrate: L-arginine	Lactobacillus gasseri DSM 20243	?	-	?
additional information	no substrate: L-arginine	Oenococcus oeni IOEB 89006	?	-	?

Synonyms

Synonyms	Comment	Organism
ODC	-	Levilactobacillus brevis
ODC	-	Lacticaseibacillus casei
ODC	-	Lactobacillus gasseri

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism
0.05	-	L-2,4-diaminobutanoate	30°C, pH 5.5	Oenococcus oeni
0.09	-	L-lysine	30°C, pH 5.5	Oenococcus oeni
0.14	-	L-ornithine	30°C, pH 7.5	Lactobacillus gasseri
0.35	-	L-2,4-diaminobutanoate	30°C, pH 7.5	Lactobacillus gasseri
0.45	-	L-2,4-diaminobutanoate	30°C, pH 5.5	Levilactobacillus brevis
0.5	-	L-2,4-diaminobutanoate	30°C, pH 7.5	Lacticaseibacillus casei
0.57	-	L-lysine	30°C, pH 5.5	Levilactobacillus brevis
4.8	-	L-ornithine	30°C, pH 5.5	Levilactobacillus brevis
6.9	-	L-ornithine	30°C, pH 5.5	Oenococcus oeni

General Information

General Information	Comment	Organism
physiological function	ornithine decarboxylase from Lactobacillus brevis is coupled to an ornithine/putrescine transmembrane exchanger. Their combined activities results in the extracellular release of putrescine	Levilactobacillus brevis
physiological function	ornithine decarboxylase from Oenococcus oeni is coupled to an ornithine/putrescine transmembrane exchanger. Their combined activities results in the extracellular release of putrescine	Oenococcus oeni
physiological function	ornithine decarboxylase system of Lacobacillus casei is composed of a decarboxylase active on ornithine and L-2,4-diaminobutyric acid and a transporter that mediates unidirectional transport of ornithine into the cytoplasm	Lacticaseibacillus casei
physiological function	ornithine decarboxylase system of Lacobacillus gasseri is composed of a decarboxylase active on ornithine and L-2,4-diaminobutyric acid and a transporter that mediates unidirectional transport of ornithine into the cytoplasm	Lactobacillus gasseri

kcat/KM [mM/s]

kcat/KM Value [1/mMs^-1]	kcat/KM Value Maximum [1/mMs^-1]	Substrate	Comment	Organism
0.01	-	L-2,4-diaminobutanoate	30°C, pH 7.5	Lacticaseibacillus casei
0.01	-	L-2,4-diaminobutanoate	30°C, pH 5.5	Oenococcus oeni
0.02	-	L-ornithine	30°C, pH 7.5	Lactobacillus gasseri
0.02	-	L-lysine	30°C, pH 5.5	Oenococcus oeni
0.03	-	L-2,4-diaminobutanoate	30°C, pH 7.5	Lactobacillus gasseri
0.04	-	L-2,4-diaminobutanoate	30°C, pH 5.5	Levilactobacillus brevis
0.08	-	L-lysine	30°C, pH 5.5	Levilactobacillus brevis
4.7	-	L-ornithine	30°C, pH 5.5	Levilactobacillus brevis
9.2	-	L-ornithine	30°C, pH 5.5	Oenococcus oeni