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Literature summary for 4.1.1.17 extracted from

  • Ansari, K.M.; Das, M.
    Skin tumor promotion by argemone oil/alkaloid in mice: evidence for enhanced cell proliferation, ornithine decarboxylase, cyclooxygenase-2 and activation of MAPK/NF-kappaB pathway (2010), Food Chem. Toxicol., 48, 132-138.
    View publication on PubMed
Search for more literature for 4.1.1.17

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Mus musculus 5829
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
skin
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-ornithine
-
 Mus musculus putrescine + CO2
-
 ?

Synonyms

Synonyms Comment Organism
ODC
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus single topical application of argemone oil (0.05-0.4 ml/mouse) or sanguinarine alkaloid (0.0015-0.012 mM/mouse) affords significant increase in ornithine decarboxylase activity and protein expression, the maximum induction of ODC activity (335%) occurs at 4 h with argemone oil, which comes down to 56% after 8h exposure time. Sanguinarine alkaloid shows 213% and 233% induction of ODC activity after 2 and 4 h, respectively. Maximum induction of ODC activity (7fold) occurs at 4 h after application of 12-O-tetradecanoyl phorbol myristate acetate and by 8 h the activity returns to the control level up