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Literature summary for 4.1.1.17 extracted from

  • Liao, Y.F.; Hung, H.C.; Hour, T.C.; Hsu, P.C.; Kao, M.C.; Tsay, G.J.; Liu, G.Y.
    Curcumin induces apoptosis through an ornithine decarboxylase-dependent pathway in human promyelocytic leukemia HL-60 cells (2008), Life Sci., 82, 367-375.
    View publication on PubMed
Search for more literature for 4.1.1.17

Application

Application Comment Organism
pharmacology ODC is a target for chemoprevention of apoptosis Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
overexpression of ODC in human promyelocytic leukemia HL-60 parental cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information ornithine decarboxylase overexpression prevents TNF-alpha- and methotrexate-induced apoptosis via reduction of reactive oxygen species, e.g. in curcumin-induced apoptosis, ODC overexpression prevents cytochrome c release and the activation of caspase-9 and caspase-3 following curcumin treatment, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-ornithine Homo sapiens ODC is the rate-limiting enzyme in polyamine biosynthesis putrescine + CO2
-
 ?
additional information Homo sapiens curcumin-induced apoptosis occurs through a mechanism of down-regulating ODC and along a ROS-dependent mitochondria-mediated pathway ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HL-60 cell
-
 Homo sapiens
-
promyelocytic leukemia cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-ornithine
-
 Homo sapiens putrescine + CO2
-
 ?
L-ornithine ODC is the rate-limiting enzyme in polyamine biosynthesis Homo sapiens putrescine + CO2
-
 ?
additional information curcumin-induced apoptosis occurs through a mechanism of down-regulating ODC and along a ROS-dependent mitochondria-mediated pathway Homo sapiens ?
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens