Application | Comment | Organism |
---|---|---|
pharmacology | ODC is a target for chemoprevention of apoptosis | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
overexpression of ODC in human promyelocytic leukemia HL-60 parental cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | ornithine decarboxylase overexpression prevents TNF-alpha- and methotrexate-induced apoptosis via reduction of reactive oxygen species, e.g. in curcumin-induced apoptosis, ODC overexpression prevents cytochrome c release and the activation of caspase-9 and caspase-3 following curcumin treatment, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-ornithine | Homo sapiens | ODC is the rate-limiting enzyme in polyamine biosynthesis | putrescine + CO2 | - |
? | |
additional information | Homo sapiens | curcumin-induced apoptosis occurs through a mechanism of down-regulating ODC and along a ROS-dependent mitochondria-mediated pathway | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HL-60 cell | - |
Homo sapiens | - |
promyelocytic leukemia cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-ornithine | - |
Homo sapiens | putrescine + CO2 | - |
? | |
L-ornithine | ODC is the rate-limiting enzyme in polyamine biosynthesis | Homo sapiens | putrescine + CO2 | - |
? | |
additional information | curcumin-induced apoptosis occurs through a mechanism of down-regulating ODC and along a ROS-dependent mitochondria-mediated pathway | Homo sapiens | ? | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |