Literature summary for 4.1.1.17 extracted from

Rounbehler, R.J.; Li, W.; Hall, M.A.; Yang, C.; Fallahi, M.; Cleveland, J.L.
Targeting ornithine decarboxylase impairs development of MYCN-amplified neuroblastoma (2009), Cancer Res., 69, 547-553.

Search for more literature for 4.1.1.17

Cloned(Commentary)

Cloned (Comment)	Organism
expression in transgenic mice expressing the human MYCN gene under the control of the rat tyrosine hydroxylase promoter	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	construction of transgenic mice expressing the human MYCN gene under the control of the rat tyrosine hydroxylase promoter, targeting ornithine decarboxylase impairs development of MYCN-amplified neuroblastoma	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
alpha-difluoromethylornithine	DFMO, a Odc suicide inhibitor, selective anticancer effects of DFMO on mouse and human MYCN-amplified neuroblastoma, overview	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-ornithine	Homo sapiens	Odc is the first and rate-limiting enzyme of polyamine biosynthesis	putrescine + CO2	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
neuroblastoma cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-ornithine	-	Homo sapiens	putrescine + CO2	-	?
L-ornithine	Odc is the first and rate-limiting enzyme of polyamine biosynthesis	Homo sapiens	putrescine + CO2	-	?

Synonyms

Synonyms	Comment	Organism
ODC	-	Homo sapiens

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Release 2023.1 (January 2023)