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Literature summary for 4.1.1.17 extracted from
- Expression of ornithine decarboxylase in precancerous and cancerous gastric lesions (2007), World J. Gastroenterol., 13, 2867-2871.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | activation of ODC is related to tumor promotion and progression | Homo sapiens |
Application
| Application | Comment | Organism |
|---|---|---|
| diagnostics | ODC may be used as a good biomarker in the screening and diagnosis of precancerous lesions | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| alpha-difluoromethylornithine | irreversible inhibitor of ODC | Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-ornithine | Homo sapiens | ODC is the first-rate limiting enzyme in the polyamine biosynthesis pathway, ODC plays a critical role in cell proliferation, and it is implicated as an essential promoter in normal cell cycles, activation of ODC is related to tumor promotion and progression, overview, expression of ODC is increased in gastric atrophy | putrescine + CO2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
patients with chronic superficial gastritis, chronic atrophic gastritis with and without intestinal metaplasia, gastric dysplasia, and gastric cancer | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| breast cancer cell | - |
Homo sapiens | - |
| colonic cancer cell | - |
Homo sapiens | - |
| gastric gland | ODC expression level is positively correlated with the degree of malignity of gastric mucosa and development of gastric lesions in precancerous and cancerous gastric lesions, overview | Homo sapiens | - |
| gastrinoma cell | - |
Homo sapiens | - |
| glioma cell | - |
Homo sapiens | - |
| lung cancer cell | - |
Homo sapiens | - |
| additional information | ODC is overexpressed in a variety of cancer cells | Homo sapiens | - |
| pancreatic cancer cell | - |
Homo sapiens | - |
| prostate cancer cell | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
immunohistochemical assay of ODC protein in gastric precancerous and cancerous lesions, overview | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-ornithine | - |
Homo sapiens | putrescine + CO2 | - |
? | |
| L-ornithine | ODC is the first-rate limiting enzyme in the polyamine biosynthesis pathway, ODC plays a critical role in cell proliferation, and it is implicated as an essential promoter in normal cell cycles, activation of ODC is related to tumor promotion and progression, overview, expression of ODC is increased in gastric atrophy | Homo sapiens | putrescine + CO2 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ODC | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | - |
Homo sapiens | |
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