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Literature summary for 4.1.1.17 extracted from

  • Persson, L.
    Ornithine decarboxylase and S-adenosylmethionine decarboxylase in trypanosomatids (2007), Biochem. Soc. Trans., 35, 314-317.
    View publication on PubMed

Application

Application Comment Organism
drug development the enzyme of the parasite is a potential target for the development of new drugs for treatment of disease such as African sleeping sickness Trypanosoma brucei
drug development the enzyme of the parasite is a potential target for the development of new drugs for treatment of diseases such as African sleeping sickness or Chagas disease Trypanosoma cruzi
drug development the enzyme of the parasite is a potential target for the development of new drugs for treatment of diseases such as African sleeping sickness or cutaneous leishmaniasis Leishmania sp.
drug development the enzyme of the parasite is a potential target for the development of new drugs for treatment of diseases such as African sleeping sickness or visceral leishmaniasis Leishmania donovani

Cloned(Commentary)

Cloned (Comment) Organism
gene odc, expression as stable enzyme in Trypanosoma cruzi makes the parasite overcome the exogenous putrescine requirement for growth Crithidia fasciculata

General Stability

General Stability Organism
ODC is rapidly degraded in mammalian cells as well as in a rabbit reticulocyte lysate system, ODC contains degradation signals that are also functionally active in mammalian cells involving the 26 S proteasome Crithidia fasciculata
the enzyme is stable compared to mammalia or Crithida fasciculata and Phytomonas sp. enzymes, which are rapidly degraded, overview Trypanosoma brucei
the enzyme is stable compared to mammalia or Crithida fasciculata and Phytomonas sp. enzymes, which are rapidly degraded, overview Leishmania donovani
the enzyme is stable compared to mammalia or Crithida fasciculata and Phytomonas sp. enzymes, which are rapidly degraded, overview Trypanosoma cruzi
the enzyme is stable compared to mammalia or Crithida fasciculata and Phytomonas sp. enzymes, which are rapidly degraded, overview Leishmania sp.

Inhibitors

Inhibitors Comment Organism Structure
alpha-difluoromethylornithine an enzyme-activated irreversible inhibitor, effective sue to the slow turnover of the trypanosomatid enzyme Leishmania donovani
alpha-difluoromethylornithine an enzyme-activated irreversible inhibitor, effective sue to the slow turnover of the trypanosomatid enzyme Leishmania sp.
alpha-difluoromethylornithine an enzyme-activated irreversible inhibitor, effective sue to the slow turnover of the trypanosomatid enzyme Trypanosoma brucei
alpha-difluoromethylornithine an enzyme-activated irreversible inhibitor, effective sue to the slow turnover of the trypanosomatid enzyme Trypanosoma cruzi

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-ornithine Crithidia fasciculata ODC is a key enzyme in the polyamine biosynthetic pathway putrescine + CO2
-
?
L-ornithine Leishmania donovani ODC is a key enzyme in the polyamine biosynthetic pathway putrescine + CO2
-
?
L-ornithine Trypanosoma cruzi ODC is a key enzyme in the polyamine biosynthetic pathway putrescine + CO2
-
?
L-ornithine Leishmania sp. ODC is a key enzyme in the polyamine biosynthetic pathway putrescine + CO2
-
?
L-ornithine Phytomonas sp. ODC is a key enzyme in the polyamine biosynthetic pathway putrescine + CO2
-
?
L-ornithine Trypanosoma brucei ODC is a key enzyme in the polyamine biosynthetic pathway, polyamines are substrates for the synthesis of trypanothione, which is essential for the protection of the parasite against reactive oxygen species produced by the host putrescine + CO2
-
?
L-ornithine Phytomonas sp. T274 ODC is a key enzyme in the polyamine biosynthetic pathway putrescine + CO2
-
?
additional information Leishmania donovani ODC degradation is not triggered by ubiquitination, the polyamines induce the degradation of ODC by affecting the synthesis of antizyme ?
-
?
additional information Trypanosoma cruzi ODC degradation is not triggered by ubiquitination, the polyamines induce the degradation of ODC by affecting the synthesis of antizyme ?
-
?
additional information Leishmania sp. ODC degradation is not triggered by ubiquitination, the polyamines induce the degradation of ODC by affecting the synthesis of antizyme ?
-
?
additional information Trypanosoma brucei ODC degradation is not triggered by ubiquitination, the polyamines induce the degradation of ODC by affecting the synthesis of antizyme, Trypanosoma brucei replicates extracellularly in the bloodstream of the host and is thus dependent on endogenous polyamines ?
-
?
additional information Crithidia fasciculata ODC is rapidly degraded in mammalian cells as well as in a rabbit reticulocyte lysate system, ODC contains degradation signals that are also functionally active in mammalian cells involving the 26 S proteasome, degradation involves the PEST sequence in the N-terminal extension, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Crithidia fasciculata
-
-
-
Leishmania donovani
-
a trypanosomatid parasite causing visceral leishmaniasis, constitutive enzyme
-
Leishmania sp.
-
a trypanosomatid parasite causing cutaneous leishmaniasis, constitutive enzyme
-
Phytomonas sp.
-
-
-
Phytomonas sp. T274
-
-
-
Trypanosoma brucei
-
ssp. gambiense causing the West African form of sleeping sickness
-
Trypanosoma cruzi
-
a trypanosomatid causing Chagas disease, constitutive enzyme
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-ornithine
-
Trypanosoma brucei putrescine + CO2
-
?
L-ornithine
-
Crithidia fasciculata putrescine + CO2
-
?
L-ornithine
-
Leishmania donovani putrescine + CO2
-
?
L-ornithine
-
Trypanosoma cruzi putrescine + CO2
-
?
L-ornithine
-
Leishmania sp. putrescine + CO2
-
?
L-ornithine
-
Phytomonas sp. putrescine + CO2
-
?
L-ornithine ODC is a key enzyme in the polyamine biosynthetic pathway Crithidia fasciculata putrescine + CO2
-
?
L-ornithine ODC is a key enzyme in the polyamine biosynthetic pathway Leishmania donovani putrescine + CO2
-
?
L-ornithine ODC is a key enzyme in the polyamine biosynthetic pathway Trypanosoma cruzi putrescine + CO2
-
?
L-ornithine ODC is a key enzyme in the polyamine biosynthetic pathway Leishmania sp. putrescine + CO2
-
?
L-ornithine ODC is a key enzyme in the polyamine biosynthetic pathway Phytomonas sp. putrescine + CO2
-
?
L-ornithine ODC is a key enzyme in the polyamine biosynthetic pathway, polyamines are substrates for the synthesis of trypanothione, which is essential for the protection of the parasite against reactive oxygen species produced by the host Trypanosoma brucei putrescine + CO2
-
?
L-ornithine
-
Phytomonas sp. T274 putrescine + CO2
-
?
L-ornithine ODC is a key enzyme in the polyamine biosynthetic pathway Phytomonas sp. T274 putrescine + CO2
-
?
additional information ODC degradation is not triggered by ubiquitination, the polyamines induce the degradation of ODC by affecting the synthesis of antizyme Leishmania donovani ?
-
?
additional information ODC degradation is not triggered by ubiquitination, the polyamines induce the degradation of ODC by affecting the synthesis of antizyme Trypanosoma cruzi ?
-
?
additional information ODC degradation is not triggered by ubiquitination, the polyamines induce the degradation of ODC by affecting the synthesis of antizyme Leishmania sp. ?
-
?
additional information ODC degradation is not triggered by ubiquitination, the polyamines induce the degradation of ODC by affecting the synthesis of antizyme, Trypanosoma brucei replicates extracellularly in the bloodstream of the host and is thus dependent on endogenous polyamines Trypanosoma brucei ?
-
?
additional information ODC is rapidly degraded in mammalian cells as well as in a rabbit reticulocyte lysate system, ODC contains degradation signals that are also functionally active in mammalian cells involving the 26 S proteasome, degradation involves the PEST sequence in the N-terminal extension, overview Crithidia fasciculata ?
-
?

Synonyms

Synonyms Comment Organism
ODC
-
Trypanosoma brucei
ODC
-
Crithidia fasciculata
ODC
-
Leishmania donovani
ODC
-
Trypanosoma cruzi
ODC
-
Leishmania sp.
ODC
-
Phytomonas sp.