Application | Comment | Organism |
---|---|---|
drug development | the enzyme of the parasite is a potential target for the development of new drugs for treatment of disease such as African sleeping sickness | Trypanosoma brucei |
drug development | the enzyme of the parasite is a potential target for the development of new drugs for treatment of diseases such as African sleeping sickness or Chagas disease | Trypanosoma cruzi |
drug development | the enzyme of the parasite is a potential target for the development of new drugs for treatment of diseases such as African sleeping sickness or cutaneous leishmaniasis | Leishmania sp. |
drug development | the enzyme of the parasite is a potential target for the development of new drugs for treatment of diseases such as African sleeping sickness or visceral leishmaniasis | Leishmania donovani |
Cloned (Comment) | Organism |
---|---|
gene odc, expression as stable enzyme in Trypanosoma cruzi makes the parasite overcome the exogenous putrescine requirement for growth | Crithidia fasciculata |
General Stability | Organism |
---|---|
ODC is rapidly degraded in mammalian cells as well as in a rabbit reticulocyte lysate system, ODC contains degradation signals that are also functionally active in mammalian cells involving the 26 S proteasome | Crithidia fasciculata |
the enzyme is stable compared to mammalia or Crithida fasciculata and Phytomonas sp. enzymes, which are rapidly degraded, overview | Trypanosoma brucei |
the enzyme is stable compared to mammalia or Crithida fasciculata and Phytomonas sp. enzymes, which are rapidly degraded, overview | Leishmania donovani |
the enzyme is stable compared to mammalia or Crithida fasciculata and Phytomonas sp. enzymes, which are rapidly degraded, overview | Trypanosoma cruzi |
the enzyme is stable compared to mammalia or Crithida fasciculata and Phytomonas sp. enzymes, which are rapidly degraded, overview | Leishmania sp. |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
alpha-difluoromethylornithine | an enzyme-activated irreversible inhibitor, effective sue to the slow turnover of the trypanosomatid enzyme | Leishmania donovani | |
alpha-difluoromethylornithine | an enzyme-activated irreversible inhibitor, effective sue to the slow turnover of the trypanosomatid enzyme | Leishmania sp. | |
alpha-difluoromethylornithine | an enzyme-activated irreversible inhibitor, effective sue to the slow turnover of the trypanosomatid enzyme | Trypanosoma brucei | |
alpha-difluoromethylornithine | an enzyme-activated irreversible inhibitor, effective sue to the slow turnover of the trypanosomatid enzyme | Trypanosoma cruzi |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-ornithine | Crithidia fasciculata | ODC is a key enzyme in the polyamine biosynthetic pathway | putrescine + CO2 | - |
? | |
L-ornithine | Leishmania donovani | ODC is a key enzyme in the polyamine biosynthetic pathway | putrescine + CO2 | - |
? | |
L-ornithine | Trypanosoma cruzi | ODC is a key enzyme in the polyamine biosynthetic pathway | putrescine + CO2 | - |
? | |
L-ornithine | Leishmania sp. | ODC is a key enzyme in the polyamine biosynthetic pathway | putrescine + CO2 | - |
? | |
L-ornithine | Phytomonas sp. | ODC is a key enzyme in the polyamine biosynthetic pathway | putrescine + CO2 | - |
? | |
L-ornithine | Trypanosoma brucei | ODC is a key enzyme in the polyamine biosynthetic pathway, polyamines are substrates for the synthesis of trypanothione, which is essential for the protection of the parasite against reactive oxygen species produced by the host | putrescine + CO2 | - |
? | |
L-ornithine | Phytomonas sp. T274 | ODC is a key enzyme in the polyamine biosynthetic pathway | putrescine + CO2 | - |
? | |
additional information | Leishmania donovani | ODC degradation is not triggered by ubiquitination, the polyamines induce the degradation of ODC by affecting the synthesis of antizyme | ? | - |
? | |
additional information | Trypanosoma cruzi | ODC degradation is not triggered by ubiquitination, the polyamines induce the degradation of ODC by affecting the synthesis of antizyme | ? | - |
? | |
additional information | Leishmania sp. | ODC degradation is not triggered by ubiquitination, the polyamines induce the degradation of ODC by affecting the synthesis of antizyme | ? | - |
? | |
additional information | Trypanosoma brucei | ODC degradation is not triggered by ubiquitination, the polyamines induce the degradation of ODC by affecting the synthesis of antizyme, Trypanosoma brucei replicates extracellularly in the bloodstream of the host and is thus dependent on endogenous polyamines | ? | - |
? | |
additional information | Crithidia fasciculata | ODC is rapidly degraded in mammalian cells as well as in a rabbit reticulocyte lysate system, ODC contains degradation signals that are also functionally active in mammalian cells involving the 26 S proteasome, degradation involves the PEST sequence in the N-terminal extension, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Crithidia fasciculata | - |
- |
- |
Leishmania donovani | - |
a trypanosomatid parasite causing visceral leishmaniasis, constitutive enzyme | - |
Leishmania sp. | - |
a trypanosomatid parasite causing cutaneous leishmaniasis, constitutive enzyme | - |
Phytomonas sp. | - |
- |
- |
Phytomonas sp. T274 | - |
- |
- |
Trypanosoma brucei | - |
ssp. gambiense causing the West African form of sleeping sickness | - |
Trypanosoma cruzi | - |
a trypanosomatid causing Chagas disease, constitutive enzyme | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-ornithine | - |
Trypanosoma brucei | putrescine + CO2 | - |
? | |
L-ornithine | - |
Crithidia fasciculata | putrescine + CO2 | - |
? | |
L-ornithine | - |
Leishmania donovani | putrescine + CO2 | - |
? | |
L-ornithine | - |
Trypanosoma cruzi | putrescine + CO2 | - |
? | |
L-ornithine | - |
Leishmania sp. | putrescine + CO2 | - |
? | |
L-ornithine | - |
Phytomonas sp. | putrescine + CO2 | - |
? | |
L-ornithine | ODC is a key enzyme in the polyamine biosynthetic pathway | Crithidia fasciculata | putrescine + CO2 | - |
? | |
L-ornithine | ODC is a key enzyme in the polyamine biosynthetic pathway | Leishmania donovani | putrescine + CO2 | - |
? | |
L-ornithine | ODC is a key enzyme in the polyamine biosynthetic pathway | Trypanosoma cruzi | putrescine + CO2 | - |
? | |
L-ornithine | ODC is a key enzyme in the polyamine biosynthetic pathway | Leishmania sp. | putrescine + CO2 | - |
? | |
L-ornithine | ODC is a key enzyme in the polyamine biosynthetic pathway | Phytomonas sp. | putrescine + CO2 | - |
? | |
L-ornithine | ODC is a key enzyme in the polyamine biosynthetic pathway, polyamines are substrates for the synthesis of trypanothione, which is essential for the protection of the parasite against reactive oxygen species produced by the host | Trypanosoma brucei | putrescine + CO2 | - |
? | |
L-ornithine | - |
Phytomonas sp. T274 | putrescine + CO2 | - |
? | |
L-ornithine | ODC is a key enzyme in the polyamine biosynthetic pathway | Phytomonas sp. T274 | putrescine + CO2 | - |
? | |
additional information | ODC degradation is not triggered by ubiquitination, the polyamines induce the degradation of ODC by affecting the synthesis of antizyme | Leishmania donovani | ? | - |
? | |
additional information | ODC degradation is not triggered by ubiquitination, the polyamines induce the degradation of ODC by affecting the synthesis of antizyme | Trypanosoma cruzi | ? | - |
? | |
additional information | ODC degradation is not triggered by ubiquitination, the polyamines induce the degradation of ODC by affecting the synthesis of antizyme | Leishmania sp. | ? | - |
? | |
additional information | ODC degradation is not triggered by ubiquitination, the polyamines induce the degradation of ODC by affecting the synthesis of antizyme, Trypanosoma brucei replicates extracellularly in the bloodstream of the host and is thus dependent on endogenous polyamines | Trypanosoma brucei | ? | - |
? | |
additional information | ODC is rapidly degraded in mammalian cells as well as in a rabbit reticulocyte lysate system, ODC contains degradation signals that are also functionally active in mammalian cells involving the 26 S proteasome, degradation involves the PEST sequence in the N-terminal extension, overview | Crithidia fasciculata | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ODC | - |
Trypanosoma brucei |
ODC | - |
Crithidia fasciculata |
ODC | - |
Leishmania donovani |
ODC | - |
Trypanosoma cruzi |
ODC | - |
Leishmania sp. |
ODC | - |
Phytomonas sp. |