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Literature summary for 4.1.1.17 extracted from

  • Assaraf, Y.G.; Kahana, C.; Spira, D.T.; Bachrach, U.
    Plasmodium falciparum: purification, properties, and immunochemical study of ornithine decarboxylase, the key enzyme in polyamine biosynthesis (1988), Exp. Parasitol., 67, 20-30.
    View publication on PubMed
Search for more literature for 4.1.1.17

Inhibitors

Inhibitors Comment Organism Structure
alpha-DL-difluoromethylornithine irreversibel Plasmodium falciparum
putrescine
-
 Plasmodium falciparum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.052
-
 L-Orn
-
 Plasmodium falciparum

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Plasmodium falciparum 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-Orn Plasmodium falciparum key enzyme in polyamine metabolism ?
-
 ?
L-Orn Plasmodium falciparum FCR 3TC key enzyme in polyamine metabolism ?
-
 ?

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum
-
-
-
Plasmodium falciparum FCR 3TC
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Plasmodium falciparum

Source Tissue

Source Tissue Comment Organism Textmining

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
7.8
-
-
 Plasmodium falciparum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Orn
-
 Plasmodium falciparum Putrescine + CO2
-
 ?
L-Orn
-
 Plasmodium falciparum FCR 3TC Putrescine + CO2
-
 ?
L-Orn key enzyme in polyamine metabolism Plasmodium falciparum ?
-
 ?
L-Orn key enzyme in polyamine metabolism Plasmodium falciparum FCR 3TC ?
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
-
 Plasmodium falciparum

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate required Plasmodium falciparum