Literature summary for 4.1.1.17 extracted from

Phillips, M.A.; Coffino, P.; Wang, C.C.
Trypanosoma brucei ornithine decarboxylase: enzyme purification, characterization, and expression in Escherichia coli (1988), J. Biol. Chem., 263, 17933-17941.

Search for more literature for 4.1.1.17

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Trypanosoma brucei

Inhibitors

Inhibitors	Comment	Organism	Structure
alpha-DL-difluoromethylornithine	irreversibel	Trypanosoma brucei
additional information	the enzyme is an important target for antitrypanosomal chemotherapy	Trypanosoma brucei

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.28	-	L-Orn	native enzyme	Trypanosoma brucei
0.33	-	L-Orn	recombinant enzyme	Trypanosoma brucei

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
45000	-	2 * 45000, SDS-PAGE	Trypanosoma brucei
90000	-	native enzyme, gel filtration	Trypanosoma brucei
92000	-	recombinant enzyme, gel filtration	Trypanosoma brucei

Organism

Organism	UniProt	Comment	Textmining
Trypanosoma brucei	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Trypanosoma brucei

Source Tissue

Source Tissue	Comment	Organism	Textmining
trypomastigote	-	Trypanosoma brucei	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
additional information	-	-	Trypanosoma brucei

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-Orn	-	Trypanosoma brucei	Putrescine + CO2	-	?

Subunits

Subunits	Comment	Organism
dimer	2 * 45000, SDS-PAGE	Trypanosoma brucei

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)