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Literature summary for 4.1.1.12 extracted from

  • Tate, S.S.; Meister, A.
    L-Aspartate-beta-decarboxylase. Structure, catalytic activities, and allosteric regulation (1971), Adv. Enzymol. Relat. Areas Mol. Biol., 35, 503-543.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
2-Oxo-5-carbamidopentanoate activates Alcaligenes faecalis
2-oxo-5-guanidinopentanoate activates Alcaligenes faecalis
2-oxoglutarate activates Alcaligenes faecalis
2-oxoglutarate activates Achromobacter sp.
2-oxoglutarate activates Pseudomonas dacunhae
2-Oxoisohexanoate activates Alcaligenes faecalis
2-oxoisopentanoate activates Alcaligenes faecalis
2-Oxomalonate activates Alcaligenes faecalis
2-oxophenylacetate activates Alcaligenes faecalis
beta-cyano-L-Ala competitive towards L-Asp Alcaligenes faecalis
D-2-Oxo-3-methylpentanoate activates Alcaligenes faecalis
glyoxylate activates Alcaligenes faecalis
glyoxylate activates Achromobacter sp.
L-2-Oxo-3-methylpentanoate activates Alcaligenes faecalis
additional information interacts with a number of vitamin B6 5'-phosphate analogues Alcaligenes faecalis
phenylpyruvate activates Alcaligenes faecalis
pyruvate activates Alcaligenes faecalis
pyruvate activates Achromobacter sp.

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.024
-
erythro-beta-hydroxyaspartate
-
Alcaligenes faecalis
0.063
-
beta-chloro-L-Ala
-
Alcaligenes faecalis
0.089
-
threo-beta-hydroxyaspartate
-
Alcaligenes faecalis
0.68
-
L-Asp
-
Alcaligenes faecalis
3
-
aminomalonate
-
Alcaligenes faecalis
4.8
-
L-cysteinesulfinate
-
Alcaligenes faecalis

Organism

Organism UniProt Comment Textmining
Acetobacter sp.
-
-
-
Achromobacter sp.
-
-
-
Alcaligenes faecalis
-
-
-
Astacoidea
-
-
-
Bombyx mori
-
-
-
Clostridium perfringens
-
-
-
Desulfovibrio desulfuricans
-
-
-
Lobster
-
-
-
Nocardia globerula
-
-
-
Pseudomonas dacunhae
-
-
-
Pseudomycobacteria
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Aminomalonate
-
Alcaligenes faecalis Gly + CO2
-
?
beta-chloro-L-Ala + H2O
-
Alcaligenes faecalis pyruvate + Cl- + NH4+
-
?
erythro-beta-Hydroxyaspartate
-
Alcaligenes faecalis L-Ser + CO2
-
?
L-Asp
-
Alcaligenes faecalis L-Ala + CO2
-
?
L-Asp
-
Bombyx mori L-Ala + CO2
-
?
L-Asp
-
Achromobacter sp. L-Ala + CO2
-
?
L-Asp
-
Nocardia globerula L-Ala + CO2
-
?
L-Asp
-
Pseudomonas dacunhae L-Ala + CO2
-
?
L-Asp
-
Pseudomycobacteria L-Ala + CO2
-
?
L-Asp
-
Clostridium perfringens L-Ala + CO2
-
?
L-Asp
-
Desulfovibrio desulfuricans L-Ala + CO2
-
?
L-Asp
-
Acetobacter sp. L-Ala + CO2
-
?
L-Asp
-
Astacoidea L-Ala + CO2
-
?
L-Asp
-
Lobster L-Ala + CO2
-
?
L-Cysteinesulfinate
-
Alcaligenes faecalis L-Ala + SO2
-
?
L-Cysteinesulfinate
-
Pseudomonas dacunhae L-Ala + SO2
-
?
additional information
-
Pseudomonas dacunhae ?
-
?
additional information transamination between L-Asp and pyruvate Alcaligenes faecalis ?
-
?
threo-beta-Hydroxyaspartate
-
Alcaligenes faecalis L-Ser + CO2
-
?

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
Alcaligenes faecalis
pyridoxal 5'-phosphate
-
Achromobacter sp.
pyridoxal 5'-phosphate activates Pseudomonas dacunhae
pyridoxal 5'-phosphate activates Clostridium perfringens