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Literature summary for 4.1.1.110 extracted from

  • Vinokur, J.M.; Cummins, M.C.; Korman, T.P.; Bowie, J.U.
    An adaptation to life in acid through a novel mevalonate pathway (2016), Sci. Rep., 6, 39737 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.1.1.110

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Thermoplasma acidophilum
expressed in Escherichia coli BL21(DE3) cells Picrophilus torridus
expressed in Escherichia coli BL21(DE3) cells Thermoplasma volcanium

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
89000
-
 gel filtration Thermoplasma acidophilum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(R)-3,5-bisphosphomevalonate Thermoplasma acidophilum
-
 isopentenyl phosphate + CO2 + phosphate
-
 ?
(R)-3,5-bisphosphomevalonate Picrophilus torridus
-
 isopentenyl phosphate + CO2 + phosphate
-
 ?
(R)-3,5-bisphosphomevalonate Thermoplasma volcanium
-
 isopentenyl phosphate + CO2 + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Picrophilus torridus Q6L1T9
-
-
Thermoplasma acidophilum
-
-
-
Thermoplasma volcanium Q97BM8
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-NTA column chromatography Thermoplasma acidophilum
Ni-NTA column chromatography Picrophilus torridus
Ni-NTA column chromatography Thermoplasma volcanium

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(R)-3,5-bisphosphomevalonate
-
 Thermoplasma acidophilum isopentenyl phosphate + CO2 + phosphate
-
 ?
(R)-3,5-bisphosphomevalonate
-
 Picrophilus torridus isopentenyl phosphate + CO2 + phosphate
-
 ?
(R)-3,5-bisphosphomevalonate
-
 Thermoplasma volcanium isopentenyl phosphate + CO2 + phosphate
-
 ?

Subunits

Subunits Comment Organism
homodimer 2 * 46300, calculated from amino acid sequence Thermoplasma acidophilum

Synonyms

Synonyms Comment Organism
MBD
-
 Thermoplasma acidophilum
MBD
-
 Picrophilus torridus
MBD
-
 Thermoplasma volcanium
mevalonate 3,5-bisphosphate decarboxylase
-
 Thermoplasma acidophilum
mevalonate 3,5-bisphosphate decarboxylase
-
 Picrophilus torridus
mevalonate 3,5-bisphosphate decarboxylase
-
 Thermoplasma volcanium
Mevalonate pyrophosphate decarboxylase
-
 Thermoplasma acidophilum
Mevalonate pyrophosphate decarboxylase
-
 Picrophilus torridus
Mevalonate pyrophosphate decarboxylase
-
 Thermoplasma volcanium