Literature summary for 4.1.1.11 extracted from

Gliessman, J.R.; Kremer, T.A.; Sangani, A.A.; Jones-Burrage, S.E.; McKinlay, J.B.
Pantothenate auxotrophy in Zymomonas mobilis ZM4 is due to a lack of aspartate decarboxylase activity (2017), FEMS Microbiol. Lett., 364, fnx113 .

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Cloned(Commentary)

Cloned (Comment)	Organism
gene panD, functional recombinant expression in enzyme-deficient Zymomonas mobilis strain ZM4, the heterologous expression of the Escherichia coli enzyme eliminates the need for exogenous pantothenate by the auxotrophic strain, that is incapable of making both beta-alanine and pantoate. beta-Alanine can substitute for pantothenate (pan) to support strain ZM4 growth	Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-aspartate	Escherichia coli	-	beta-alanine + CO2	-	?

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	P0A790	-	-
no activity in Zymomonas mobilis	-	Zymomonas mobilis ZM4 is auxotrophic for beta-alanine but not for pantoate. Strain ZM4 shows pantothenate auxotrophy due to the absence of the single gene, panD, encoding aspartate 1-decarboxylase. Heterologous expression of Escherichia coli PanD in Zymomonas mobilis or supplementation of the growth medium with the product of PanD activity, beta-alanine, eliminates the need for exogenous pantothenate	-
no activity in Zymomonas mobilis ZM4 / ATCC 31821 / CP4	-	Zymomonas mobilis ZM4 is auxotrophic for beta-alanine but not for pantoate. Strain ZM4 shows pantothenate auxotrophy due to the absence of the single gene, panD, encoding aspartate 1-decarboxylase. Heterologous expression of Escherichia coli PanD in Zymomonas mobilis or supplementation of the growth medium with the product of PanD activity, beta-alanine, eliminates the need for exogenous pantothenate	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-aspartate	-	Escherichia coli	beta-alanine + CO2	-	?

Synonyms

Synonyms	Comment	Organism
PanD	-	Escherichia coli

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Release 2023.1 (January 2023)