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Literature summary for 4.1.1.11 extracted from

  • Wang, Y.; Xu, H.; White, R.H.
    beta-Alanine biosynthesis in Methanocaldococcus jannaschii (2014), J. Bacteriol., 196, 2869-2875.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.1.1.11

Cloned(Commentary)

Cloned (Comment) Organism
-
 Methanocaldococcus jannaschii

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.8
-
 L-aspartate pH 8.0, 70°C Methanocaldococcus jannaschii

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-aspartate Methanocaldococcus jannaschii the product beta-alanine is required for the biosynthesis of coenzyme A beta-alanine + CO2
-
 ?
L-aspartate Methanocaldococcus jannaschii DSM 2661 the product beta-alanine is required for the biosynthesis of coenzyme A beta-alanine + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Methanocaldococcus jannaschii Q60358
-
-
Methanocaldococcus jannaschii DSM 2661 Q60358
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.09
-
 pH 8.0, 70°C, recombinant enzyme Methanocaldococcus jannaschii

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-aspartate
-
 Methanocaldococcus jannaschii beta-alanine + CO2
-
 ?
L-aspartate the product beta-alanine is required for the biosynthesis of coenzyme A Methanocaldococcus jannaschii beta-alanine + CO2
-
 ?
L-aspartate
-
 Methanocaldococcus jannaschii DSM 2661 beta-alanine + CO2
-
 ?
L-aspartate the product beta-alanine is required for the biosynthesis of coenzyme A Methanocaldococcus jannaschii DSM 2661 beta-alanine + CO2
-
 ?

Synonyms

Synonyms Comment Organism
MfnA
-
 Methanocaldococcus jannaschii
MJ0050 locus name Methanocaldococcus jannaschii
PLP-dependent L-aspartate decarboxylase
-
 Methanocaldococcus jannaschii

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
70
-
 assay at Methanocaldococcus jannaschii

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Methanocaldococcus jannaschii

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Methanocaldococcus jannaschii

General Information

General Information Comment Organism
physiological function the MJ0050 gene complements the Escherichia coli panD deletion mutant cells, in which panD encoding aspartate decarboxylase in Escherichia coli has been knocked out, thus confirming the function of this gene in vivo Methanocaldococcus jannaschii