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Literature summary for 4.1.1.1 extracted from

  • Huettl, S.; Fiebig, J.; Kutter, S.; Hause, G.; Lilie, H.; Spinka, M.; Koenig, S.
    Catalytically active filaments - pyruvate decarboxylase from Neurospora crassa. pH-controlled oligomer structure and catalytic function (2012), FEBS J., 279, 275-284.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information lack of substrate activation in Neurospora crassa yeast pyruvate decarboxylase species Neurospora crassa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information steady-state kinetic analysis, overview. The v/[S] plots display negative cooperativity and hence deviate from Michaelis-Menten kinetics in just the opposite way Neurospora crassa

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Neurospora crassa

Organism

Organism UniProt Comment Textmining
Neurospora crassa
-
-
-

Subunits

Subunits Comment Organism
oligomer the enzyme forms filamentous structures at pH 6.0-6.5 of octamers and dodecamers, NcPDC tetramers display the lowest catalytic efficiency among all functional oligomeric forms of this enzyme, analysis by analytical gel filtration, analytical ultracentrifugation and small-angle X-ray solution scattering Neurospora crassa

Synonyms

Synonyms Comment Organism
NcPDC
-
Neurospora crassa

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Neurospora crassa

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
6.1
-
pyruvate kcat per monomer, pH 7.0, 25°C Neurospora crassa
12.5
-
pyruvate kcat per monomer, pH 6.5, 25°C Neurospora crassa
14
-
pyruvate kcat per monomer, pH 6.0, MES-NaOH buffer, 25°C Neurospora crassa
16.9
-
pyruvate kcat per monomer, pH 5.5, 25°C Neurospora crassa
17.2
-
pyruvate kcat per monomer, pH 5.0, 25°C Neurospora crassa
18.3
-
pyruvate kcat per monomer, pH 6.0, phosphate buffer, 25°C Neurospora crassa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5 6
-
Neurospora crassa

pH Range

pH Minimum pH Maximum Comment Organism
5 7 pH-dependence overview Neurospora crassa

Cofactor

Cofactor Comment Organism Structure
thiamine diphosphate
-
Neurospora crassa

General Information

General Information Comment Organism
additional information the enzyme forms filamentous structures Neurospora crassa