Literature summary for 3.8.1.7 extracted from

Xu, D.; Wei, Y.; Wu, J.; Dunaway-Mariano, D.; Guo, H.; Cui, Q.; Gao, J.
QM/MM studies of the enzyme-catalyzed dechlorination of 4-chlorobenzoyl-CoA provide insight into reaction energetics (2004), J. Am. Chem. Soc., 126, 13649-13658.

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Protein Variants

Protein Variants	Comment	Organism
G113A	mutation significantly increases the barrier by disrupting the hydrogen bond with the Gly114 backbone	Pseudomonas sp.

Organism

Organism	UniProt	Comment	Textmining
Pseudomonas sp.	A5JTM5	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
4-chlorobenzoyl-CoA + H2O	reaction rate is limited by the formation of the Meisenheimer comlex, rather than by its decomposition	Pseudomonas sp.	4-hydroxybenzoyl-CoA + chloride	-	?

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Release 2023.1 (January 2023)