Literature summary for 3.8.1.5 extracted from

Buryska, T.; Daniel, L.; Kunka, A.; Brezovsky, J.; Damborsky, J.; Prokop, Z.
Discovery of novel haloalkane dehalogenase inhibitors (2016), Appl. Environ. Microbiol., 82, 1958-1965 .

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli BL21(DE3) cells	Mycobacterium tuberculosis

Inhibitors

Inhibitors	Comment	Organism	Structure
1-(4-oxo-4-phenylbutyl)-1H-1,2,4-triazole-3-carbonitrile	-	Mycobacterium tuberculosis
1-[(4-oxo-1,9a-dihydro-4H-pyrido[1,2-a]pyrimidin-2-yl)methyl]-1H-1,2,4-triazole-3-carbonitrile	-	Mycobacterium tuberculosis
1-[4-[(2H-1,3-benzodioxol-5-yl)oxy]but-2-yn-1-yl]-4-(4-methoxyphenyl)piperazine	-	Mycobacterium tuberculosis
2,5-dimethyl-N-[1-[3-(trifluoromethyl)phenyl]ethyl]-1H-pyrrole-3-carboxamide	-	Mycobacterium tuberculosis
2-([methyl[(5-methyl-1,2-oxazol-3-yl)methyl]amino]methyl)quinazolin-4(3H)-one	-	Mycobacterium tuberculosis
2-oxo-N-[3-(1H-pyrazol-5-yl)phenyl]-1,2,3,4-tetrahydroquinoline-6-carboxamide	-	Mycobacterium tuberculosis
2-phenyl-5-(4H-1,2,4-triazol-4-yl)-1,3-benzoxazole	-	Mycobacterium tuberculosis
5-bromo-N-[[4-(1H-pyrazol-5-yl)phenyl]methyl]furan-2-carboxamide	-	Mycobacterium tuberculosis
5-[(tetrazolo[1,5-b]pyridazin-6-yl)amino]-1,3-dihydro-2H-benzimidazol-2-one	-	Mycobacterium tuberculosis
6-[(2-phenylpyrimidin-5-yl)oxy]tetrazolo[1,5-b]pyridazine	-	Mycobacterium tuberculosis
6-[5-(3-chlorophenyl)-2H-tetrazol-2-yl]-1,2,3,8a-tetrahydrotetrazolo[1,5-b]pyridazine	-	Mycobacterium tuberculosis
cyano(quinolin-3-yl)methyl benzoate	-	Mycobacterium tuberculosis
ethyl 4-oxo-3-phenyl-3,4-dihydropyrazolo[5,1-d][1,2,3,5]tetrazine-8-carboxylate	-	Mycobacterium tuberculosis
N-methyl-N-[(4-oxo-1,4-dihydroquinazolin-2-yl)methyl]-2-(1H-1,2,4-triazol-1-yl)acetamide	-	Mycobacterium tuberculosis
N-[(furan-2-yl)methyl]-3-phenyl-1,2,4-oxadiazole-5-carboxamide	-	Mycobacterium tuberculosis
N-[2-(1H-imidazol-1-yl)ethyl]-6-phenylpyridazin-3-amine	-	Mycobacterium tuberculosis
N-[[4-(pyrrolidin-1-yl)phenyl]methyl]-4H-1,2,4-triazol-4-amine	-	Mycobacterium tuberculosis

Organism

Organism	UniProt	Comment	Textmining
Mycobacterium tuberculosis	P9WMR9	-	-
Mycobacterium tuberculosis H37Rv	P9WMR9	-	-

Synonyms

Synonyms	Comment	Organism
dmbA	-	Mycobacterium tuberculosis

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Release 2023.1 (January 2023)