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Literature summary for 3.7.1.5 extracted from

  • Jones, D.C.N.; Cooper, R.A.
    Catabolism of 3-hydroxybenzoate by the gentisate pathway in Klebsiella pneumoniae M5a1 (1990), Arch. Microbiol., 154, 489-495.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Klebsiella pneumoniae
-
activity occurs also in strains OH101, MI214, and MI214/1
-
Klebsiella pneumoniae M5al
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activity occurs also in strains OH101, MI214, and MI214/1
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information strain M5al grows well on 3-hydroxybenzoate, 2,5-dihydroxybenzoate (gentisate), and 3,4-dihydroxybenzoate (protocatechuate), but does not grow on 4-hydroxybenzoate. Growth on 3-hydroxybenzoate and 2,5-dihydroxybenzoate leads to the induction of 3-hydroxybenzoate monooxygenase, 2,5-dihydroxybenzoate dioxygenase, maleylpyruvate isomerase and fumarylpyruvate hydrolase Klebsiella pneumoniae
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-fumarylpyruvate + H2O
-
Klebsiella pneumoniae fumarate + pyruvate
-
?
3-fumarylpyruvate + H2O
-
Klebsiella pneumoniae M5al fumarate + pyruvate
-
?
3-fumarylpyruvate + H2O
-
Klebsiella pneumoniae M5a1 fumarate + pyruvate
-
?

Synonyms

Synonyms Comment Organism
fumarylpyruvate hydrolase
-
Klebsiella pneumoniae

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Klebsiella pneumoniae

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.1
-
assay at Klebsiella pneumoniae

Expression

Organism Comment Expression
Klebsiella pneumoniae growth on 3-hydroxybenzoate and 2,5-dihydroxybenzoate leads to the induction of fumarylpyruvate hydrolase up

General Information

General Information Comment Organism
metabolism the enzyme catalyzes the last step in the gentisate pathway for 3-hydroxybenzoate catabolism Klebsiella pneumoniae