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Literature summary for 3.7.1.4 extracted from

  • Piepoli, A.; Schirru, E.; Mastrorilli, A.; Gentile, A.; Cotugno, R.; Quitadamo, M.; Merla, A.; Congia, M.; Usai Satta, P.; Perri, F.
    Genotyping of the lactase-phlorizin hydrolase c/t-13910 polymorphism by means of a new rapid denaturing high-performance liquid chromatography-based assay in healthy subjects and colorectal cancer patients (2007), J. Biomol. Screen., 12, 733-739.
    View publication on PubMed
Search for more literature for 3.7.1.4

Application

Application Comment Organism
medicine adult-type hypolactasia results from the progressive decline of lactase-phlorizin hydrolase activity in enterocytes after weaning, lactase nonpersistence may determine a primary lactose intolerance with reduced diary product consumption, which is possibly related to an increased risk of colon cancer Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information the genetic variant C/T-13910 upstream of the lactase-phlorizin hydrolase gene is strongly correlated with the lactase persistence/nonperistence trait Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phloretin + H2O Homo sapiens
-
 phloretate + phloroglucinol
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood blood samples are used for genotyping Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
lactose + H2O
-
 Homo sapiens D-glucose + D-galactose
-
 ?
phloretin + H2O
-
 Homo sapiens phloretate + phloroglucinol
-
 ?

Synonyms

Synonyms Comment Organism
lactase-phlorizin hydrolase
-
 Homo sapiens
LPH
-
 Homo sapiens
phloretin hydrolase
-
 Homo sapiens