Literature summary for 3.7.1.3 extracted from

Liu, Y.; Feng, X.; Lai, J.; Yi, W.; Yang, J.; Du, T.; Long, X.; Zhang, Y.; Xiao, Y.
A novel role of kynureninase in the growth control of breast cancer cells and its relationships with breast cancer (2019), J. Cell. Mol. Med., 23, 6700-6707 .

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q16719	-	-

Synonyms

Synonyms	Comment	Organism
KYNU	-	Homo sapiens

General Information

General Information	Comment	Organism
metabolism	the role of the enzyme (KYNU) in cancer cell proliferation, tumour growth and development is evaluated by MTT assay, soft agar colony formation assay and xenograft mouse models. Among 137 primary breast cancer tissues, 46.7% (64/137) have high KYNU expression while 53.3% have low KYNU expression. The expression of KYNU is positively correlated with the expressions of biomarkers ER, PR and E-cad, while negatively associated with tumour grade, tumour stage and the expressions of biomarker HER2 and Ki-67. Overexpression of KYNU significantly inhibits cell proliferation in cell culture, colony formation in soft agar and xenograft BC development in NOD/SCID mice. Kynureninase suppresses breast cancer cell proliferation, tumour growth and development	Homo sapiens
physiological function	kynureninase may function as a tumour suppressor in breast cancer	Homo sapiens

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Release 2023.1 (January 2023)