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Literature summary for 3.7.1.3 extracted from

  • Phillips, R.S.; Sundararaju, B.; Koushik, S.V.
    The catalytic mechanism of kynureninase from Pseudomonas fluorescens: Evidence for transient quinonoid and ketimine intermediates from rapid-scanning stopped-flow spectrophotometry (1998), Biochemistry, 37, 8783-8789.
    View publication on PubMed
Search for more literature for 3.7.1.3

Application

Application Comment Organism
medicine tryptophan metabolism Pseudomonas fluorescens

Inhibitors

Inhibitors Comment Organism Structure
benzaldehyde
-
 Pseudomonas fluorescens
o-aminoacetophenone
-
 Pseudomonas fluorescens
o-aminobenzaldehyde
-
 Pseudomonas fluorescens
o-nitrobenzaldehyde
-
 Pseudomonas fluorescens
S-(2-aminophenyl)-L-cysteine S,S-dioxide transition state analogue Pseudomonas fluorescens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-alanine + pyridoxal 5'-phosphate Pseudomonas fluorescens
-
 pyruvate + pyridoxamine 5'-phosphate
-
 ?
L-kynurenine + H2O Pseudomonas fluorescens
-
 anthranilate + L-alanine
-
 ?

Organism

Organism UniProt Comment Textmining
Pseudomonas fluorescens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Pseudomonas fluorescens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-alanine + pyridoxal 5'-phosphate
-
 Pseudomonas fluorescens pyruvate + pyridoxamine 5'-phosphate
-
 ?
L-kynurenine + H2O
-
 Pseudomonas fluorescens anthranilate + L-alanine
-
 ?

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Pseudomonas fluorescens