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Literature summary for 3.7.1.3 extracted from

  • Carpenedo, R.; Chiarugi, A.; Russi, P.; Lombardi, G.; Carlำ, V.; Pellicciari, R.; Mattoli, L.; Moroni, F.
    Inhibitors of kynurenine hydroxylase and kynureninase increase cerebral formation of kynurenate and have sedative and anticonvulsant activities (1994), Neuroscience, 61, 237-244.
    View publication on PubMed
Search for more literature for 3.7.1.3

Application

Application Comment Organism
medicine tryptophan metabolism Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
m-nitrobenzoylalanine
-
 Rattus norvegicus
nicotinylalanine
-
 Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.2
-
 L-kynurenine
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
kynurenine + H2O Rattus norvegicus
-
 quinolinate
-
 ?
L-kynurenine + H2O Rattus norvegicus
-
 anthranilate + L-alanine
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
kynurenine + H2O
-
 Rattus norvegicus excitotoxin quinolinate
-
 ?
kynurenine + H2O
-
 Rattus norvegicus quinolinate
-
 ?
L-kynurenine + H2O
-
 Rattus norvegicus anthranilate + L-alanine
-
 ?