Application | Comment | Organism |
---|---|---|
medicine | tryptophan metabolism | Homo sapiens |
medicine | tryptophan metabolism | Rattus norvegicus |
medicine | tryptophan metabolism | Suncus murinus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.013 | - |
L-3-hydroxykynurenine | - |
Rattus norvegicus | |
0.018 | - |
L-3-hydroxykynurenine | - |
Suncus murinus | |
0.077 | - |
L-3-hydroxykynurenine | - |
Homo sapiens | |
0.24 | - |
L-kynurenine | - |
Rattus norvegicus | |
0.25 | - |
L-kynurenine | - |
Suncus murinus | |
1 | - |
L-kynurenine | - |
Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
95000 | - |
- |
Rattus norvegicus |
110000 | - |
- |
Suncus murinus |
130000 | - |
- |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3-hydroxy-L-kynurenine + H2O | Homo sapiens | - |
3-hydroxyanthranilate + L-Ala | - |
? | |
3-hydroxy-L-kynurenine + H2O | Rattus norvegicus | - |
3-hydroxyanthranilate + L-Ala | - |
? | |
3-hydroxy-L-kynurenine + H2O | Suncus murinus | - |
3-hydroxyanthranilate + L-Ala | - |
? | |
L-kynurenine + H2O | Homo sapiens | - |
anthranilate + L-alanine | - |
? | |
L-kynurenine + H2O | Rattus norvegicus | - |
anthranilate + L-alanine | - |
? | |
L-kynurenine + H2O | Suncus murinus | - |
anthranilate + L-alanine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Suncus murinus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adrenal gland | - |
Homo sapiens | - |
adrenal gland | - |
Rattus norvegicus | - |
adrenal gland | - |
Suncus murinus | - |
brain | - |
Homo sapiens | - |
brain | - |
Rattus norvegicus | - |
brain | - |
Suncus murinus | - |
heart | - |
Homo sapiens | - |
heart | - |
Rattus norvegicus | - |
heart | - |
Suncus murinus | - |
intestinal muscle | - |
Homo sapiens | - |
intestinal muscle | - |
Rattus norvegicus | - |
intestinal muscle | - |
Suncus murinus | - |
kidney | - |
Homo sapiens | - |
kidney | - |
Rattus norvegicus | - |
kidney | - |
Suncus murinus | - |
liver | - |
Homo sapiens | - |
liver | - |
Rattus norvegicus | - |
liver | - |
Suncus murinus | - |
lung | - |
Homo sapiens | - |
lung | - |
Rattus norvegicus | - |
lung | - |
Suncus murinus | - |
muscle | - |
Rattus norvegicus | - |
muscle | - |
Suncus murinus | - |
ovary | - |
Homo sapiens | - |
pancreas | - |
Homo sapiens | - |
pancreas | - |
Rattus norvegicus | - |
pancreas | - |
Suncus murinus | - |
spleen | - |
Homo sapiens | - |
spleen | - |
Rattus norvegicus | - |
spleen | - |
Suncus murinus | - |
thymus | - |
Suncus murinus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.0002 | - |
liver | Rattus norvegicus |
0.0007 | - |
liver | Homo sapiens |
0.026 | - |
liver | Suncus murinus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3-hydroxy-L-kynurenine + H2O | - |
Homo sapiens | 3-hydroxyanthranilate + L-alanine | - |
? | |
3-hydroxy-L-kynurenine + H2O | - |
Rattus norvegicus | 3-hydroxyanthranilate + L-alanine | - |
? | |
3-hydroxy-L-kynurenine + H2O | - |
Suncus murinus | 3-hydroxyanthranilate + L-alanine | - |
? | |
3-hydroxy-L-kynurenine + H2O | - |
Homo sapiens | 3-hydroxyanthranilate + L-Ala | - |
? | |
3-hydroxy-L-kynurenine + H2O | - |
Rattus norvegicus | 3-hydroxyanthranilate + L-Ala | - |
? | |
3-hydroxy-L-kynurenine + H2O | - |
Suncus murinus | 3-hydroxyanthranilate + L-Ala | - |
? | |
L-kynurenine + H2O | - |
Homo sapiens | anthranilate + L-alanine | - |
? | |
L-kynurenine + H2O | - |
Rattus norvegicus | anthranilate + L-alanine | - |
? | |
L-kynurenine + H2O | - |
Suncus murinus | anthranilate + L-alanine | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | - |
Rattus norvegicus |
dimer | - |
Suncus murinus |