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Literature summary for 3.7.1.3 extracted from

  • Okuno, E.; Kido, R.
    Kynureninase and kynurenine 3-hydroxylase in mammalian tissues (1991), Adv. Exp. Med. Biol., 294, 167-176.
    View publication on PubMed

Application

Application Comment Organism
medicine tryptophan metabolism Homo sapiens
medicine tryptophan metabolism Rattus norvegicus
medicine tryptophan metabolism Suncus murinus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.013
-
L-3-hydroxykynurenine
-
Rattus norvegicus
0.018
-
L-3-hydroxykynurenine
-
Suncus murinus
0.077
-
L-3-hydroxykynurenine
-
Homo sapiens
0.24
-
L-kynurenine
-
Rattus norvegicus
0.25
-
L-kynurenine
-
Suncus murinus
1
-
L-kynurenine
-
Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
95000
-
-
Rattus norvegicus
110000
-
-
Suncus murinus
130000
-
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3-hydroxy-L-kynurenine + H2O Homo sapiens
-
3-hydroxyanthranilate + L-Ala
-
?
3-hydroxy-L-kynurenine + H2O Rattus norvegicus
-
3-hydroxyanthranilate + L-Ala
-
?
3-hydroxy-L-kynurenine + H2O Suncus murinus
-
3-hydroxyanthranilate + L-Ala
-
?
L-kynurenine + H2O Homo sapiens
-
anthranilate + L-alanine
-
?
L-kynurenine + H2O Rattus norvegicus
-
anthranilate + L-alanine
-
?
L-kynurenine + H2O Suncus murinus
-
anthranilate + L-alanine
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-
Suncus murinus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland
-
Homo sapiens
-
adrenal gland
-
Rattus norvegicus
-
adrenal gland
-
Suncus murinus
-
brain
-
Homo sapiens
-
brain
-
Rattus norvegicus
-
brain
-
Suncus murinus
-
heart
-
Homo sapiens
-
heart
-
Rattus norvegicus
-
heart
-
Suncus murinus
-
intestinal muscle
-
Homo sapiens
-
intestinal muscle
-
Rattus norvegicus
-
intestinal muscle
-
Suncus murinus
-
kidney
-
Homo sapiens
-
kidney
-
Rattus norvegicus
-
kidney
-
Suncus murinus
-
liver
-
Homo sapiens
-
liver
-
Rattus norvegicus
-
liver
-
Suncus murinus
-
lung
-
Homo sapiens
-
lung
-
Rattus norvegicus
-
lung
-
Suncus murinus
-
muscle
-
Rattus norvegicus
-
muscle
-
Suncus murinus
-
ovary
-
Homo sapiens
-
pancreas
-
Homo sapiens
-
pancreas
-
Rattus norvegicus
-
pancreas
-
Suncus murinus
-
spleen
-
Homo sapiens
-
spleen
-
Rattus norvegicus
-
spleen
-
Suncus murinus
-
thymus
-
Suncus murinus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0002
-
liver Rattus norvegicus
0.0007
-
liver Homo sapiens
0.026
-
liver Suncus murinus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-hydroxy-L-kynurenine + H2O
-
Homo sapiens 3-hydroxyanthranilate + L-alanine
-
?
3-hydroxy-L-kynurenine + H2O
-
Rattus norvegicus 3-hydroxyanthranilate + L-alanine
-
?
3-hydroxy-L-kynurenine + H2O
-
Suncus murinus 3-hydroxyanthranilate + L-alanine
-
?
3-hydroxy-L-kynurenine + H2O
-
Homo sapiens 3-hydroxyanthranilate + L-Ala
-
?
3-hydroxy-L-kynurenine + H2O
-
Rattus norvegicus 3-hydroxyanthranilate + L-Ala
-
?
3-hydroxy-L-kynurenine + H2O
-
Suncus murinus 3-hydroxyanthranilate + L-Ala
-
?
L-kynurenine + H2O
-
Homo sapiens anthranilate + L-alanine
-
?
L-kynurenine + H2O
-
Rattus norvegicus anthranilate + L-alanine
-
?
L-kynurenine + H2O
-
Suncus murinus anthranilate + L-alanine
-
?

Subunits

Subunits Comment Organism
dimer
-
Rattus norvegicus
dimer
-
Suncus murinus