Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.7.1.3 extracted from

  • Soda, K.; Tanizawa, K.
    Kynureninases: Enzymological properties and regulation mechanism (1979), Adv. Enzymol. Relat. Areas Mol. Biol., 49, 1-40.
    View publication on PubMed
Search for more literature for 3.7.1.3

Application

Application Comment Organism
medicine tryptophan metabolism Cavia porcellus
medicine tryptophan metabolism Mus musculus
medicine tryptophan metabolism Homo sapiens
medicine tryptophan metabolism Rattus norvegicus
medicine tryptophan metabolism Saccharomyces cerevisiae
medicine tryptophan metabolism Bos taurus
medicine tryptophan metabolism Neurospora crassa
medicine tryptophan metabolism Aspergillus niger
medicine tryptophan metabolism Pseudomonas fluorescens
medicine tryptophan metabolism Canis lupus familiaris
medicine tryptophan metabolism Pseudomonas marginalis
medicine tryptophan metabolism Penicillium roqueforti
medicine tryptophan metabolism Chondrichthyes
medicine tryptophan metabolism aves
medicine tryptophan metabolism Rhizopus stolonifer
medicine tryptophan metabolism Xanthomonas arboricola pv. pruni
medicine tryptophan metabolism Testudines
medicine tryptophan metabolism amphibia

Crystallization (Commentary)

Crystallization (Comment) Organism
-
 Neurospora crassa
-
 Pseudomonas fluorescens
-
 Pseudomonas marginalis

Inhibitors

Inhibitors Comment Organism Structure
cadaverine
-
 Neurospora crassa
delta-N-acetyl-L-ornithine
-
 Neurospora crassa
delta-N-acetyl-L-ornithine
-
 Pseudomonas marginalis
DL-dihydroxyphenylalanine
-
 Neurospora crassa
HgCl2
-
 Neurospora crassa
HgCl2
-
 Pseudomonas marginalis
L-lysine
-
 Neurospora crassa
L-ornithine
-
 Neurospora crassa
L-ornithine
-
 Pseudomonas marginalis
NH2OH
-
 Neurospora crassa
NH2OH
-
 Pseudomonas marginalis
p-chloromercuribenzoate
-
 Neurospora crassa
p-chloromercuribenzoate
-
 Pseudomonas marginalis
phenylhydrazine-HCl
-
 Neurospora crassa
phenylhydrazine-HCl
-
 Pseudomonas marginalis
putrescine
-
 Neurospora crassa
pyridoxal 5'-phosphate
-
 Neurospora crassa
Sodium borohydride
-
 Neurospora crassa
Sodium borohydride
-
 Pseudomonas marginalis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.003
-
 3-hydroxy-L-kynurenine
-
 Neurospora crassa
0.006
-
 kynurenine
-
 Neurospora crassa
0.0067
-
 L-kynurenine constitutive enzyme Saccharomyces cerevisiae
0.018
-
 L-kynurenine
-
 Xanthomonas arboricola pv. pruni
0.034
-
 L-kynurenine constitutive enzyme Neurospora crassa
0.035
-
 L-kynurenine
-
 Pseudomonas marginalis
0.037
-
 L-3-hydroxykynurenine constitutive enzyme Neurospora crassa
0.039 0.0714 L-kynurenine
-
 Pseudomonas fluorescens
0.05
-
 L-3-hydroxykynurenine
-
 Pseudomonas fluorescens
0.2
-
 L-3-hydroxykynurenine
-
 Pseudomonas marginalis
0.22
-
 L-3-hydroxykynurenine
-
 Xanthomonas arboricola pv. pruni
0.54
-
 L-3-hydroxykynurenine constitutive enzyme Saccharomyces cerevisiae
2.2
-
 N'-formyl-L-kynurenine
-
 Pseudomonas fluorescens
2.2
-
 N'-formyl-L-kynurenine
-
 Pseudomonas marginalis

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Neurospora crassa

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
46000
-
 2 * 46000, SDS-PAGE Pseudomonas marginalis
50000
-
 2 * 50000 Neurospora crassa
92000
-
 gel filtration Pseudomonas marginalis
100000
-
 sedimentation equilibrium method Pseudomonas marginalis
105000
-
 gel filtration Neurospora crassa
110000
-
 constitutive and inducible enzyme, gel filtration Neurospora crassa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3-hydroxy-L-kynurenine + H2O Cavia porcellus
-
 3-hydroxyanthranilate + L-Ala
-
 ?
3-hydroxy-L-kynurenine + H2O Mus musculus
-
 3-hydroxyanthranilate + L-Ala
-
 ?
3-hydroxy-L-kynurenine + H2O Homo sapiens
-
 3-hydroxyanthranilate + L-Ala
-
 ?
3-hydroxy-L-kynurenine + H2O Rattus norvegicus
-
 3-hydroxyanthranilate + L-Ala
-
 ?
3-hydroxy-L-kynurenine + H2O Saccharomyces cerevisiae
-
 3-hydroxyanthranilate + L-Ala
-
 ?
3-hydroxy-L-kynurenine + H2O Bos taurus
-
 3-hydroxyanthranilate + L-Ala
-
 ?
3-hydroxy-L-kynurenine + H2O Neurospora crassa
-
 3-hydroxyanthranilate + L-Ala
-
 ?
3-hydroxy-L-kynurenine + H2O Aspergillus niger
-
 3-hydroxyanthranilate + L-Ala
-
 ?
3-hydroxy-L-kynurenine + H2O Pseudomonas fluorescens
-
 3-hydroxyanthranilate + L-Ala
-
 ?
3-hydroxy-L-kynurenine + H2O Canis lupus familiaris
-
 3-hydroxyanthranilate + L-Ala
-
 ?
3-hydroxy-L-kynurenine + H2O Pseudomonas marginalis
-
 3-hydroxyanthranilate + L-Ala
-
 ?
3-hydroxy-L-kynurenine + H2O Penicillium roqueforti
-
 3-hydroxyanthranilate + L-Ala
-
 ?
3-hydroxy-L-kynurenine + H2O Chondrichthyes
-
 3-hydroxyanthranilate + L-Ala
-
 ?
3-hydroxy-L-kynurenine + H2O aves
-
 3-hydroxyanthranilate + L-Ala
-
 ?
3-hydroxy-L-kynurenine + H2O Rhizopus stolonifer
-
 3-hydroxyanthranilate + L-Ala
-
 ?
3-hydroxy-L-kynurenine + H2O Xanthomonas arboricola pv. pruni
-
 3-hydroxyanthranilate + L-Ala
-
 ?
3-hydroxy-L-kynurenine + H2O Testudines
-
 3-hydroxyanthranilate + L-Ala
-
 ?
3-hydroxy-L-kynurenine + H2O amphibia
-
 3-hydroxyanthranilate + L-Ala
-
 ?
L-kynurenine + H2O Cavia porcellus
-
 anthranilate + L-alanine
-
 ?
L-kynurenine + H2O Mus musculus
-
 anthranilate + L-alanine
-
 ?
L-kynurenine + H2O Homo sapiens
-
 anthranilate + L-alanine
-
 ?
L-kynurenine + H2O Rattus norvegicus
-
 anthranilate + L-alanine
-
 ?
L-kynurenine + H2O Saccharomyces cerevisiae
-
 anthranilate + L-alanine
-
 ?
L-kynurenine + H2O Bos taurus
-
 anthranilate + L-alanine
-
 ?
L-kynurenine + H2O Neurospora crassa
-
 anthranilate + L-alanine
-
 ?
L-kynurenine + H2O Aspergillus niger
-
 anthranilate + L-alanine
-
 ?
L-kynurenine + H2O Pseudomonas fluorescens
-
 anthranilate + L-alanine
-
 ?
L-kynurenine + H2O Canis lupus familiaris
-
 anthranilate + L-alanine
-
 ?
L-kynurenine + H2O Pseudomonas marginalis
-
 anthranilate + L-alanine
-
 ?
L-kynurenine + H2O Penicillium roqueforti
-
 anthranilate + L-alanine
-
 ?
L-kynurenine + H2O Chondrichthyes
-
 anthranilate + L-alanine
-
 ?
L-kynurenine + H2O aves
-
 anthranilate + L-alanine
-
 ?
L-kynurenine + H2O Rhizopus stolonifer
-
 anthranilate + L-alanine
-
 ?
L-kynurenine + H2O Xanthomonas arboricola pv. pruni
-
 anthranilate + L-alanine
-
 ?
L-kynurenine + H2O Testudines
-
 anthranilate + L-alanine
-
 ?
L-kynurenine + H2O amphibia
-
 anthranilate + L-alanine
-
 ?

Organism

Organism UniProt Comment Textmining
amphibia
-
-
-
Aspergillus niger
-
-
-
aves
-
-
-
Bos taurus
-
-
-
Canis lupus familiaris
-
-
-
Cavia porcellus
-
-
-
Chondrichthyes
-
-
-
Homo sapiens
-
-
-
Mus musculus
-
-
-
Neurospora crassa
-
-
-
Penicillium roqueforti
-
-
-
Pseudomonas fluorescens
-
-
-
Pseudomonas marginalis
-
-
-
Rattus norvegicus
-
-
-
Rhizopus stolonifer
-
-
-
Saccharomyces cerevisiae
-
 constitutive enzyme
-
Testudines
-
-
-
Xanthomonas arboricola pv. pruni
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Saccharomyces cerevisiae
-
 Pseudomonas fluorescens
-
 Pseudomonas marginalis
-
 Xanthomonas arboricola pv. pruni
constitutive and inducible enzyme Neurospora crassa

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
brain
-
 Homo sapiens
-
brain
-
 Rattus norvegicus
-
liver
-
 Cavia porcellus
-
liver
-
 Mus musculus
-
liver
-
 Homo sapiens
-
liver
-
 Rattus norvegicus
-
liver
-
 Bos taurus
-
liver
-
 Canis lupus familiaris
-
lung
-
 Mus musculus
-
lung
-
 Homo sapiens
-
lung
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0178
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-hydroxy-L-kynurenine + H2O
-
 Cavia porcellus 3-hydroxyanthranilate + L-alanine
-
 ?
3-hydroxy-L-kynurenine + H2O
-
 Mus musculus 3-hydroxyanthranilate + L-alanine
-
 ?
3-hydroxy-L-kynurenine + H2O
-
 Homo sapiens 3-hydroxyanthranilate + L-alanine
-
 ?
3-hydroxy-L-kynurenine + H2O
-
 Rattus norvegicus 3-hydroxyanthranilate + L-alanine
-
 ?
3-hydroxy-L-kynurenine + H2O
-
 Saccharomyces cerevisiae 3-hydroxyanthranilate + L-alanine
-
 ?
3-hydroxy-L-kynurenine + H2O
-
 Bos taurus 3-hydroxyanthranilate + L-alanine
-
 ?
3-hydroxy-L-kynurenine + H2O
-
 Neurospora crassa 3-hydroxyanthranilate + L-alanine
-
 ?
3-hydroxy-L-kynurenine + H2O
-
 Aspergillus niger 3-hydroxyanthranilate + L-alanine
-
 ?
3-hydroxy-L-kynurenine + H2O
-
 Pseudomonas fluorescens 3-hydroxyanthranilate + L-alanine
-
 ?
3-hydroxy-L-kynurenine + H2O
-
 Canis lupus familiaris 3-hydroxyanthranilate + L-alanine
-
 ?
3-hydroxy-L-kynurenine + H2O
-
 Pseudomonas marginalis 3-hydroxyanthranilate + L-alanine
-
 ?
3-hydroxy-L-kynurenine + H2O
-
 Penicillium roqueforti 3-hydroxyanthranilate + L-alanine
-
 ?
3-hydroxy-L-kynurenine + H2O
-
 Chondrichthyes 3-hydroxyanthranilate + L-alanine
-
 ?
3-hydroxy-L-kynurenine + H2O
-
 aves 3-hydroxyanthranilate + L-alanine
-
 ?
3-hydroxy-L-kynurenine + H2O
-
 Rhizopus stolonifer 3-hydroxyanthranilate + L-alanine
-
 ?
3-hydroxy-L-kynurenine + H2O
-
 Xanthomonas arboricola pv. pruni 3-hydroxyanthranilate + L-alanine
-
 ?
3-hydroxy-L-kynurenine + H2O
-
 Testudines 3-hydroxyanthranilate + L-alanine
-
 ?
3-hydroxy-L-kynurenine + H2O
-
 amphibia 3-hydroxyanthranilate + L-alanine
-
 ?
3-hydroxy-L-kynurenine + H2O
-
 Cavia porcellus 3-hydroxyanthranilate + L-Ala
-
 ?
3-hydroxy-L-kynurenine + H2O
-
 Mus musculus 3-hydroxyanthranilate + L-Ala
-
 ?
3-hydroxy-L-kynurenine + H2O
-
 Homo sapiens 3-hydroxyanthranilate + L-Ala
-
 ?
3-hydroxy-L-kynurenine + H2O
-
 Rattus norvegicus 3-hydroxyanthranilate + L-Ala
-
 ?
3-hydroxy-L-kynurenine + H2O
-
 Saccharomyces cerevisiae 3-hydroxyanthranilate + L-Ala
-
 ?
3-hydroxy-L-kynurenine + H2O
-
 Bos taurus 3-hydroxyanthranilate + L-Ala
-
 ?
3-hydroxy-L-kynurenine + H2O
-
 Neurospora crassa 3-hydroxyanthranilate + L-Ala
-
 ?
3-hydroxy-L-kynurenine + H2O
-
 Aspergillus niger 3-hydroxyanthranilate + L-Ala
-
 ?
3-hydroxy-L-kynurenine + H2O
-
 Pseudomonas fluorescens 3-hydroxyanthranilate + L-Ala
-
 ?
3-hydroxy-L-kynurenine + H2O
-
 Canis lupus familiaris 3-hydroxyanthranilate + L-Ala
-
 ?
3-hydroxy-L-kynurenine + H2O
-
 Pseudomonas marginalis 3-hydroxyanthranilate + L-Ala
-
 ?
3-hydroxy-L-kynurenine + H2O
-
 Penicillium roqueforti 3-hydroxyanthranilate + L-Ala
-
 ?
3-hydroxy-L-kynurenine + H2O
-
 Chondrichthyes 3-hydroxyanthranilate + L-Ala
-
 ?
3-hydroxy-L-kynurenine + H2O
-
 aves 3-hydroxyanthranilate + L-Ala
-
 ?
3-hydroxy-L-kynurenine + H2O
-
 Rhizopus stolonifer 3-hydroxyanthranilate + L-Ala
-
 ?
3-hydroxy-L-kynurenine + H2O
-
 Xanthomonas arboricola pv. pruni 3-hydroxyanthranilate + L-Ala
-
 ?
3-hydroxy-L-kynurenine + H2O
-
 Testudines 3-hydroxyanthranilate + L-Ala
-
 ?
3-hydroxy-L-kynurenine + H2O
-
 amphibia 3-hydroxyanthranilate + L-Ala
-
 ?
L-kynurenine + H2O
-
 Cavia porcellus anthranilate + L-alanine
-
 ?
L-kynurenine + H2O
-
 Mus musculus anthranilate + L-alanine
-
 ?
L-kynurenine + H2O
-
 Homo sapiens anthranilate + L-alanine
-
 ?
L-kynurenine + H2O
-
 Rattus norvegicus anthranilate + L-alanine
-
 ?
L-kynurenine + H2O
-
 Saccharomyces cerevisiae anthranilate + L-alanine
-
 ?
L-kynurenine + H2O
-
 Bos taurus anthranilate + L-alanine
-
 ?
L-kynurenine + H2O
-
 Neurospora crassa anthranilate + L-alanine
-
 ?
L-kynurenine + H2O
-
 Aspergillus niger anthranilate + L-alanine
-
 ?
L-kynurenine + H2O
-
 Pseudomonas fluorescens anthranilate + L-alanine
-
 ?
L-kynurenine + H2O
-
 Canis lupus familiaris anthranilate + L-alanine
-
 ?
L-kynurenine + H2O
-
 Pseudomonas marginalis anthranilate + L-alanine
-
 ?
L-kynurenine + H2O
-
 Penicillium roqueforti anthranilate + L-alanine
-
 ?
L-kynurenine + H2O
-
 Chondrichthyes anthranilate + L-alanine
-
 ?
L-kynurenine + H2O
-
 aves anthranilate + L-alanine
-
 ?
L-kynurenine + H2O
-
 Rhizopus stolonifer anthranilate + L-alanine
-
 ?
L-kynurenine + H2O
-
 Xanthomonas arboricola pv. pruni anthranilate + L-alanine
-
 ?
L-kynurenine + H2O
-
 Testudines anthranilate + L-alanine
-
 ?
L-kynurenine + H2O
-
 amphibia anthranilate + L-alanine
-
 ?
N-formyl-L-kynurenine + H2O
-
 Neurospora crassa N-formylanthranilate + L-alanine
-
 ?
N-formyl-L-kynurenine + H2O
-
 Pseudomonas fluorescens N-formylanthranilate + L-alanine
-
 ?
N-formyl-L-kynurenine + H2O
-
 Pseudomonas marginalis N-formylanthranilate + L-alanine
-
 ?

Subunits

Subunits Comment Organism
dimer
-
 Rattus norvegicus
dimer 2 * 46000, SDS-PAGE Pseudomonas marginalis
dimer 2 * 50000 Neurospora crassa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
-
 Rattus norvegicus
8
-
-
 Pseudomonas marginalis
8.5
-
-
 Pseudomonas fluorescens
8.5
-
 constitutive enzyme Neurospora crassa

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Rattus norvegicus
pyridoxal 5'-phosphate
-
 Neurospora crassa
pyridoxal 5'-phosphate
-
 Pseudomonas fluorescens
pyridoxal 5'-phosphate
-
 Pseudomonas marginalis