Application | Comment | Organism |
---|---|---|
medicine | hereditary tyrosinaemia type 1 results from deficiency of fumarylacetoacetase | Homo sapiens |
medicine | hereditary tyrosinaemia type 1 results from deficiency of fumarylacetoacetase | Mus musculus |
Cloned (Comment) | Organism |
---|---|
for expression in Escherichia coli | Homo sapiens |
for expression in Escherichia coli | Mus musculus |
Crystallization (Comment) | Organism |
---|---|
a high-resolution crystal structure of the FAH-CEHPOBA complex is soved at 1.35 A | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-[(3-carboxy-2-oxopropyl)hydroxyphosphinyl]acrylate | COPHPAA | Homo sapiens | |
3-[(3-carboxy-2-oxopropyl)hydroxyphosphinyl]acrylate | COPHPAA | Mus musculus | |
4-[(2-carboxyethyl)-hydroxyphosphinyl]-3-oxobutyrate | CEHPOBA | Homo sapiens | |
4-[(2-carboxyethyl)-hydroxyphosphinyl]-3-oxobutyrate | CEHPOBA | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-fumarylacetoacetate + H2O | Homo sapiens | - |
acetoacetate + fumarate | - |
? | |
4-fumarylacetoacetate + H2O | Mus musculus | - |
acetoacetate + fumarate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | P35505 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
- |
Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-fumarylacetoacetate + H2O | - |
Homo sapiens | acetoacetate + fumarate | - |
? | |
4-fumarylacetoacetate + H2O | - |
Mus musculus | acetoacetate + fumarate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
FAA hydrolase | - |
Homo sapiens |
FAA hydrolase | - |
Mus musculus |
FAH | - |
Homo sapiens |
FAH | - |
Mus musculus |
fumarylacetoacetase | - |
Homo sapiens |
fumarylacetoacetase | - |
Mus musculus |
fumarylacetoacetate hydrolase | - |
Homo sapiens |
fumarylacetoacetate hydrolase | - |
Mus musculus |
mFAH | - |
Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
activity assay | Homo sapiens |
7 | - |
activity assay | Mus musculus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000012 | - |
3-[(3-carboxy-2-oxopropyl)hydroxyphosphinyl]acrylate | - |
Homo sapiens | |
0.000041 | - |
4-[(2-carboxyethyl)-hydroxyphosphinyl]-3-oxobutyrate | - |
Homo sapiens |